This federal Project Grant award of $985,026 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the roles and mechanisms of epitranscriptomic regulation in the development and function of the mammalian nervous system, as well as the pathological consequences of disrupting these processes. The research program will utilize mouse models and human induced...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to determine the contributions of sex chromosomes and gonadal hormones in shaping acute seizure susceptibility, seizure-induced neuropathology, spontaneous recurrent seizures, and hippocampal gene expression in a mouse model of temporal lobe epilepsy. The total funding...
This federal Project Grant award of $460,500 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is aimed at developing novel bioprinting methodologies for the production of human stem cell-based organoids. The key objectives are to: 1) Create a customized bioink formulation using proteins, polysaccharides, and functionalized nanoparticles to foster the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $426,250 Project Grant under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This 2-year grant will fund research using cutting-edge voltage imaging to examine how interactions between specific neuronal circuit elements in the hippocampus relate to the development of temporal lobe...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", will fund research to develop improved screening methods for new anti-seizure medications using a Drosophila (fruit fly) model of pharmacoresistant epilepsy. The $363,602 award, effective January 21, 2025 through December 31, 2025, will support two phases of work: 1) enhancing the existing...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), provides $1,204,564.00 to Neurologic Solutions Inc. to further develop and validate the EPISCALP EEG analytics algorithm. The goal is to enhance the accuracy of epilepsy diagnosis by leveraging EPISCALP's predictive capabilities to reduce misdiagnosis rates, which currently...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a hybrid strategy for rapidly generating region-specific neural cell populations, including oligodendrocytes and neural crest progenitors, from human pluripotent stem cells. The $426,650 award to Trustees of Tufts College, effective June 1, 2025 through May 31, 2027, will...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 24-month, $430,375 Project Grant (CFDA 93.853) to Emory University to develop human organoid models for pediatric high-grade gliomas (PHGGs). The research aims to 1) create PHGG organoid models using human patient-derived cancer stem cells and 2) model how interactions between PHGG cells and the human neural microenvironment affect responses to tyrosine kinase inhibitors and other anti-tumor drugs. The goal is to...
This federal Project Grant award of $598,952.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund the development of a novel human stem cell-derived multi-cellular model to study the developmental processes underlying spinal cord midline crossing of axons. The awardee, The Leland Stanford Junior University, will generate and...
This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...