Project Grant R43NS137898

Award Date 9/19/24
Completion Date 8/31/25
Dollars Obligated $1M
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Carson, PA 15203, USA
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This $999,998 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development of Renerva LLC's Peripheral Nerve Matrix (PNM) technology. PNM is a tissue-based hydrogel derived from porcine nerve that aims to improve functional outcomes for patients with challenging peripheral nerve gap injuries.

The Phase I project will optimize the PNM formulation and mechanical properties with the goal of exceeding the performance of the "gold standard" nerve autograft in a rat critical nerve gap injury model. Key objectives include assessing in vivo motor and sensory recovery, electrophysiological function, and histological endpoints over 12 weeks. The project will also evaluate the shelf stability of the optimized PNM formulation. These efforts are expected to de-risk the PNM technology and enable a future Phase II project to determine its ability to promote recovery in large animal models of clinically relevant nerve gap injuries.

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