Project Grant R43NS119007

Acatechol, Inc. was awarded a $274,982 National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I grant to develop an innovative anti-infective coating for Foley catheters. The project aims to create a hybrid coating that combines biofilm-repellent and antimicrobial properties to provide prolonged resistance against pathogen colonization and catheter-associated urinary tract infections (CAUTIs). This work is being conducted under the NSF Technology, Innovation, and...

This $256,000 National Science Foundation project grant supports the development of an automated chest tube to prevent clotting. Circulatech LLC will design and prototype a novel chest tube that proactively manages fluid flow within the catheter lumen to flush and drain the tube, reducing blood clot formation. Through a process called "dilutional coagulopathy," the tube will use sterile saline or anticoagulants to reduce thrombosis in the drainage space rather than relying on...

This Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,989,548 to Cerulean Scientific Inc. to develop a slippery, omniphobic coating for peripheral vascular grafts. The goal is to prevent thrombosis, biofilm formation, and other complications that frequently lead to graft failure. Over the 2.75-year project period ending June 2027, the funding will support in vitro characterization of the coating's durability and...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will fund the development of a new, ultra-low-fouling coating technology by Zwicoat Materials Innovations, LLC (ZCMI). The project aims to establish the technical feasibility of applying ZCMI's patented zwitterionic coating to two existing medical implants: cochlear implant (CI) electrode arrays and...

This National Science Foundation (NSF) Cooperative Agreement award under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program provides $1,250,000 in funding to Biodevek Inc., a Boston-based small business, to develop a novel sprayable hydrogel sealant for managing gastrointestinal (GI) lesions and bleeding. The project aims to create a minimally invasive, bio-adhesive hydrogel solution that can provide sustained lesion protection and hemostasis, potentially reducing...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $350,000 Project Grant to Karios Technologies LLC to develop TissueShield, a novel single-use, ready-to-use, sterile, dual-chamber, dual-syringe sprayable hydrogel for preventing post-surgical cardiac adhesions. TissueShield is a 3-component polymer system that can be easily sprayed directly onto the heart, forming a robust anti-adhesion layer within seconds. The...

This $962,735 cooperative agreement from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships program (CFDA 47.084) supports the development of an enhanced biodegradable tissue adhesive for gastrointestinal surgical wound closure applications by Bezwada Biomedical LLC. The small business will refine a polyurethane-based adhesive formulation and assess its in vivo performance to identify a safe, easy-to-use lead tissue adhesive that can help prevent anastomotic...

This National Science Foundation Technology, Innovation, and Partnerships grant award of $250,000 provides funding from August 15, 2022 to July 31, 2024 to develop and evaluate an absorbable surgical adhesive patch to reinforce internal suture lines in the urinary tract. The University of California, Los Angeles will receive the award to create a flexible, bioabsorbable internal suture reinforcement device aimed at significantly reducing post-operative complications and readmissions for...

This Cooperative Agreement award from the National Science Foundation will support Environmental Protective Coatings LLC's development of durable, omniphobic coatings through Scops Coating Technologies LLC. Funded under NSF's Technology, Innovation, and Partnerships program (CFDA 47.084), the $1,013,950 award aims to validate pilot-scale production and enhance weatherability of fluorine-free, self-cleaning coating materials. Key objectives include pilot-scale production to enable...

This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $117,562 to Worcester Polytechnic Institute (WPI) to develop a class of bioadhesive implants through modular design. The key products and services to be delivered include: Designing, formulating, and characterizing bioadhesive implants that integrate a liquid adhesive polymer layer and a solid tissue-elasticity-matching hydrogel layer. This approach aims to...