Project Grant R43NS112050

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,499,886 to Astrocyte Pharmaceuticals Inc. to complete preclinical activities for advancing an oral tablet formulation of their proprietary small molecule drug AST-004 to clinical trials for the treatment of moderate traumatic brain injury (TBI). The key goals of this...

This federal Project Grant award of $571,404 from the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) supports research at the University of Pittsburgh focused on developing novel therapies to promote functional recovery after traumatic brain injury (TBI). The key objectives are to investigate how the adipokine hormone adiponectin can protect neurons, restore white matter, and improve cognitive...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award provides $274,855 to Mito-Biotherapeutics, Inc. to develop a novel fusion protein construct (NFP) that can cross the blood-brain barrier and deliver a therapeutic payload to repair mitochondrial DNA damage in neurons following traumatic brain injury (TBI). The project aims to attenuate neurological damage and prevent the progression of TBI to neurodegenerative diseases like...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $739,772 to Cian, Inc. to develop a cilia biomarker kit for brain injury diagnosis and prognosis. The key objectives are to develop monoclonal antibodies targeting two cilia-expressed proteins (Aim 1) and an immunoassay to detect these proteins in human plasma (Aim 2). This will...

The University of Pittsburgh is receiving a $437,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant aims to provide proof-of-concept evidence that retinoic acid (RA) can attenuate cholinergic deficits and white matter connectivity impairments after traumatic brain injury (TBI). The two-year project will: 1) determine if RA treatment...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to investigate the effects of intranasal HB-EGF treatment on brain glucose metabolism and inflammation after traumatic brain injury (TBI) in pediatric patients. The $453,970 award to the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. aims to determine whether...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding the development of an innovative portable device to rapidly detect and monitor traumatic brain injury (TBI) biomarkers. The $332,122 award to Hemex Health Inc. aims to create a point-of-care diagnostic platform that can quickly analyze whole blood samples to identify elevated...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $628,133 Project Grant (CFDA 93.853) to Rutgers, The State University to study the "Metabolic Mechanisms of Recovery in Mild TBI" from September 1, 2024 to July 31, 2028. The research aims to determine if activating the CYPIN protein can promote functional recovery after mild traumatic brain injury (TBI) in mice. This builds on previous work identifying CYPIN as a key molecule regulating methionine levels and...

The University of Georgia Research Foundation, Inc. (UGA Research Foundation) was awarded a $379,171 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports a 2-year research project to investigate cerebrovascular dysfunction and cerebral atrophy in severe traumatic brain injury (STBI). Specifically, the project aims to: 1) Characterize...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $587,521 in funding to the Regents of the University of Michigan to support research on mitochondrial modulation therapy for traumatic brain injury (TBI). The key objectives of this 5-year research project are to: (1) explore the molecular mechanisms of neurotrauma and...