Project Grant R43NS076359

This federal Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $590,302 to Purdue University and sub-awardees Beth Israel Deaconess Medical Center and UC San Diego to develop and evaluate next-generation platinum-based countermeasures and combinations with protective agents to efficiently rescue toxic cyanide exposures. The project aims to improve and down-select platinum...

This $374,378 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program is funding the development of computational models and a wearable, noninvasive carbon dioxide (CO2) sensing device. The goal is to accurately translate transcutaneous CO2 measurements (ptCO2) into clinically relevant arterial CO2 levels (paCO2), a vital...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of an electrochemical assay and point-of-care (POC) instrument for sensitive, real-time measurement of oxytocin levels. The $312,817 award to Giner Inc., a small business R&D firm in Massachusetts, will fund a Phase I program to improve and validate the current assay and build a...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $324,770 to Canairy LLC to develop an advanced, wearable device for tracking environmental exposure and evaluating respiratory response. The main objective is to create an intelligent, connected prototype that can measure personal exposure to pollutants and assess lung health, transmitting data to healthcare providers for early intervention...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $2,095,816 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The DNA Medicine Institute, Inc. to develop a rapid, 5-minute point-of-care test that can measure anti-Factor Xa activity and hemoglobin levels. This diagnostic tool is intended to guide emergency management for patients on direct oral anticoagulants, potentially enabling quicker delivery of life-saving interventions. The 2-year project,...

This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program provides $332,122 to Hemex Health Inc. to develop an innovative point-of-care device for rapidly detecting and monitoring traumatic brain injury (TBI) biomarkers from a blood sample. The device will leverage micro-engineering methods to capture and quantify specific TBI...

The National Institute of Environmental Health Sciences (NIEHS) awarded a $586,190 Project Grant (CFDA 93.113 - Environmental Health) to Ondavia, Inc. to develop a prototype in-line, autonomous system for monitoring hexavalent chromium concentrations in drinking and ground water. The Phase II SBIR project aims to convert Ondavia's successful feasibility study into a commercial-ready platform using Surface-Enhanced Raman Spectroscopy (SERS) technology. The proposed system consists of consumable...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $676,629.27 to Wayne State University to develop a high-affinity carbon monoxide (CO) scavenging hemoprotein as a potential antidote for CO poisoning and a CO-selective fluorescent reporter for studying physiological CO signaling. The key products and services to be delivered include: 1) identifying the minimum functional...

This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $306,872 to Xcellassay, Inc., a biotechnology research firm in San Francisco, California. The funding supports the development of a hand-held, bioassay-based test strip for the rapid, field-based detection of endocrine-disrupting chemicals (EDCs) in drinking water. The Phase I project aims to develop and characterize the components...