Project Grant R43MH143569
- This $449,228 Project Grant from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will enable Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for large-scale, chronic extracellular neural recording and stimulation in human brain organoids. The project aims to 1) create advanced biological assay chambers to support chronic electrophysiology while maintaining organoid health, 2) develop...
- The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
- This $1,344,223 Project Grant awarded by the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding research to develop a novel nanomaterial-based platform for noninvasive neuroengineering. The key objectives are to: Engineer ultra-bright upconversion nanoparticles that can convert near-infrared light into visible light for deep brain optogenetic stimulation. Leverage focused ultrasound to deliver the nanoparticles across the...
- This Project Grant award of $517,546, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to optimize, benchmark, and validate a novel multimodal microelectrode array (MEA) probe that integrates fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing with parallel electrical recording. The research team, led by investigators from Dartmouth College, aims to develop this integrated MEA platform...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, provides $679,072 to President and Fellows of Harvard College to establish a platform that can accurately recapitulate and perturb cortical development and morphogenesis in vitro. The goal is to develop novel technologies that can reproduce key features of human forebrain development, including patterning, morphology, and regional cellular organization, and...
- This $556,525 Project Grant was awarded on June 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant will fund the development, testing, and dissemination of micro-LED optoelectrode platforms for monitoring and perturbing targeted neurons in multiple local brain circuits. These platforms will provide a new tool for analyzing the dynamic...
- The National Institute of Mental Health (NIMH) awarded a $769,352 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Leland Stanford Junior University (Stanford University) to develop an engineered bioprinting platform to study neural migration in brain assembloids. This research aims to enhance the quality, reproducibility, and complexity of neural assembloids, which are three-dimensional cellular models representing different brain regions, to strengthen their...
- The National Institute of Mental Health (NIMH) has awarded a $992,826 Project Grant (R44MH135529) to Blackrock Microsystems, Inc. to develop the "OA2" - a high-density chronic optogenetic interface for primate brain research. The goal of this Small Business Innovation Research (SBIR) Phase I project is to engineer a new two-level optogenetic stimulation device that combines Blackrock's "Utah Optrode Array" technology with a surface-level stimulation array. This will enable...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is for the development and commercialization of an automated platform for high-throughput behavioral and electrophysiology research in freely behaving rats. The $1,266,318 award to Spikegadgets, Inc., a neuroscience research equipment company based in San Francisco, CA, will fund the creation of an integrated system that can administer operant...
- The National Institute of Mental Health (NIMH) awarded a $980,661 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Neuralthread Inc. to develop a fully integrated "TULLEKIT" system for stable, high-density neural recordings in freely moving non-human primates (NHPs). The TULLEKIT platform combines ultraflexible 384-channel probes, a minimally invasive port system for deep-brain implantation, and a wireless recording headstage to address key challenges in...
This $499,781 project grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will develop a multi-functional "ORGANOID-CRADLE" interface to measure and modulate the activity of neural organoid cultures. The ORGANOID-CRADLE will include a multi-electrode array (MEA) and light-emitting diodes (LEDs) for optogenetic experiments, with a revolutionary soft robotic structure to grip non-adherent organoid cultures and position the electrodes and LEDs on the organoid surface. This will allow the device to conform to the size and shape of the organoid, making it more versatile than current static devices. The grant was awarded to Neurolux Inc., a for-profit company in Northfield, Illinois specializing in biomedical and neuroscience technologies, and the project will run from September 2025 to September 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $499.8k | 9/24/25 |