Project Grant R43MH139167
- The National Institute of Mental Health awarded Neurolux Inc. $1.248 million on September 24, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate the Compliant Reversible Actuator and Detector Leveraging Electrophysiology for Organoids (ORGANOID-CRADLE). Neurolux will design and validate a multi-functional interface to measure and modulate neural organoid culture activity. The first-generation ORGANOID-CRADLE will integrate a multi-electrode array and...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded the University of Pittsburgh $1,004,971 through the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, to develop a platform for measuring and analyzing brain activity, cognitive states, behavior, and physiology during multiday neural recordings in individuals undergoing surgical treatment for epilepsy. The project will integrate wearable technology and artificial intelligence for behavioral and physiological monitoring alongside...
- Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded The Johns Hopkins University $538,657 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop Neural Navigator, a standardized platform for quantifying circuit pathophysiology in patient-derived cerebral organoids using multi-electrode array recordings and machine learning-based modeling to decode psychiatric disorder signatures in schizophrenia and bipolar disorder. The project aims to establish reproducible...
- The National Institute of Mental Health (NIMH) awarded a $1,380,070 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Duke University to explore the cellular properties and circuit functional roles of human cortical interneurons. This research aims to generate a multimodal phenotypic catalog of human interneurons and characterize their functional organization in neural circuits. The project will utilize live brain specimens collected from neurosurgical procedures and a novel genetic...
- The National Institute of Mental Health awarded Neuralthread Inc. $2.149 million on September 17, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop TULLEKIT, an integrated deep-brain neural recording system for non-human primates. TULLEKIT combines ultraflexible 384-channel polymer probes, a minimally invasive port system for deep-brain implantation, and a wireless recording headstage to achieve stable, high-density neural recordings in freely moving subjects. The...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Mental Health awarded the University of Illinois $440,908 on July 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating the roles of the prefrontal cortex and ventral hippocampus during adolescence in the maturation of social and cognitive behaviors. The research examines how changes in GABAergic inhibitory transmission in these limbic structures contribute to the refinement of higher cognitive functions and social...
The National Institute of Mental Health awarded $456,902 to 37Degrees, Inc. on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop INVITREON, a compact integrated platform for long-term neuronal culture incubation, recording, and closed-loop stimulation. The project runs through July 31, 2028, with performance in Chicago, Illinois. INVITREON addresses technical barriers in microelectrode array (MEA) culture systems used for disease modeling, neurotoxicity evaluation, and drug screening by simplifying equipment that has been prohibitively complex and bulky for typical neuroscientists. The platform enables high-density neuro-electrophysiological functional studies of neuronal networks, supporting investigation of neurological disorders including stroke, neonatal encephalopathy, dementia, Parkinson's disease, and epilepsy, as well as behavioral research in memory, pain, depression, anxiety, and stress. The award is classified as a Project Grant under the NIMH research grants program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $456.9k | 8/3/26 |