Project Grant R43MH135814
- This National Science Foundation (NSF) Engineering Program (CFDA 47.041) $550,000 CAREER grant award to New York University (NYU) aims to develop innovative wireless neural interface systems that can enable high-resolution neural recording, wireless power transfer, and high-bandwidth communication. The project, titled "NEUROTAP: Chip-Scale High-Resolution Neural Recording with Wireless Communication and Powering", seeks to tackle key challenges in scalable brain-machine interface...
- This NSF Engineering Program award of $605,320 to North Carolina State University (NC State) supports the development of a flexible, FMRI-compatible neural probe with multi-modal sensing and modulation capabilities. The novel probe is designed to advance understanding of neural circuit dynamics and enable closed-loop neuromodulation for treating neurological disorders. Key product elements include: Flexible, multi-shank neural probe fabricated using polymeric materials to enable deep brain...
- This Project Grant award, valued at $206,132 and provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a wireless, battery-free bioelectronic implant for closed-loop neuromodulation to treat detrusor sphincter dyssynergia (DSD) in individuals with spinal cord injury. The University of Houston System, the awardee, will fabricate and...
- This SBIR Phase I Project Grant, awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, is developing a novel minimally invasive procedure for deploying an implantable spinal cord stimulation (SCS) lead using a shape memory polymer (SMP). The $304,259 project, which runs from October 1, 2025 to June 30, 2026, aims to create an 8-channel SMP-based paddle lead that can be molded into a compact configuration for minimally...
- This Small Business Innovation Research (SBIR) Phase I project, awarded by the National Science Foundation (NSF) under the TIP (Technology, Innovation, and Partnerships) program (CFDA 47.084), aims to develop a novel, multifunctional neural probe for advancing neuroscience research. The $254,456 grant awarded to Neurobionics Inc. on August 15, 2024, will fund the integration of electrical, optical, and chemical capabilities into a single implantable device. This versatile tool will enable...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program provides $150,000 to Baylor University to conduct collaborative research on large-scale wireless RF networks of microchip sensors. The key objectives are to: 1) build a microsensor system and demonstrate low-error rate and efficient asynchronous, encoded wireless transmission in the laboratory using fabricated microchips, and 2) decode signals from a hypothetical brain implant composed of up to 8,000...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $537,650 to Spike Neuro LLC for the development of a flexible carbon fiber penetrating nerve cuff and cortical array for neural recording, stimulation, and neurochemical detection. The project aims to create advanced electrophysiology recording and stimulation tools...
- This $500,000 project grant from the National Science Foundation Division of Electrical, Communications and Cyber Systems Engineering program will fund research into magnetoelectric nanoparticles as multi-field controlled devices for wireless brain stimulation. Led by researchers at the University of Miami, the three-year project aims to experimentally study the feasibility of using magnetoelectric nanoparticles to achieve wireless deep brain stimulation with sub-millimeter spatial resolution in...
- This $600,000 Project Grant from the National Science Foundation's Division of Information and Intelligent Systems, under the Computer and Information Science and Engineering program (CFDA 47.070), will fund research at The Pennsylvania State University to develop a fully wireless, flexible electrical-acoustic implant for high-resolution neural stimulation and recording across large-scale brain circuits. The implant is intended to provide minimally invasive ultrasound neuromodulation and...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to Georgia TECH Research Corp provides $499,896.00 to develop an artificial nervous system for communication between wearable and implantable biomedical devices. The project aims to optimize emitter and receiver networks to enable coordination of sensors and therapeutic actuators throughout the body, with potential applications in areas like sciatic nerve stimulation and controlled drug...
ADDRESSING THE WIRELESS POWER PROBLEM: A LOW-POWER HYBRID RADIO FOR NEUROSCIENCE EXPERIMENTS - PROJECT SUMMARY CLOSED-LOOP STIMULATION IS KEY TO THE STUDY AND TREATMENT OF NEUROLOGICAL DISORDERS. HOWEVER, LARGELY DUE TO CURRENT WIRELESS POWER DEMANDS, STIMULATION SYSTEMS ARE RESTRICTED TO WIRED CONNECTIONS, WHICH IMPACT NATURAL BEHAVIOR, INDUCE MOTION ARTIFACTS, AND LIMIT COMPLEXITY OF STUDY DESIGN. WHILE A FEW WIRELESS RECORDING- ONLY SYSTEMS HAVE BEEN DEVELOPED, THE POWER DEMANDS OF THESE DEVICES PROHIBIT THE ADDITION OF WIRELESS ELECTRICAL STIMULATION WHILE STAYING WITHIN SIZE AND WEIGHT LIMITATIONS FOR SMALLER ANIMAL MODELS. THESE LIMITATIONS ARE ROADBLOCKS TO THE NEXT PHASE OF NEUROSCIENCE RESEARCH AND CLINICAL DEVELOPMENT. IN THIS PHASE I, 1.5 YEAR, STTR PROJECT, SPIKE NEURO IS PARTNERING WITH DUKE UNIVERSITY TO DEVELOP A NOVEL LOW POWER HYBRID BACKSCATTER RADIO FREQUENCY SYSTEM TO ENABLE THE COMMERCIALIZATION OF A SERIES OF WIRELESS RECORDING AND ELECTRICAL STIMULATION HEADSTAGES FOR SMALL AND LARGE ANIMAL ELECTROPHYSIOLOGY RESEARCH. THIS INNOVATIVE WIRELESS TECHNOLOGY SHIFTS THE HIGH-POWER DEMAND FEATURES OUT OF THE HEADWORN COMPONENTS TO THE BASE STATION, SIGNIFICANTLY REDUCING BATTERY SIZE AND WEIGHT ENABLING THE ADDITION OF THE ELECTRICAL STIMULATION COMPONENTS AND ALLOWING FOR MORE FLEXIBILITY IN RECORDING ONLY EXPERIMENTS. THIS DEVELOPMENT WORK WILL RESULT IN TWO HEADSTAGE OPTIONS FOR SMALL ANIMALS WITH 5 AND 16 CHANNELS OF RECORDING AND 2 CHANNELS OF ELECTRICAL STIMULATION AND TWO SLIGHTLY LARGER SYSTEMS FOR 32 AND 64 CHANNELS OF RECORDING WITH 8 CHANNELS OF ELECTRICAL STIMULATION. AIM 1 FOCUSES ON THE DEVELOPMENT OF THE 5 AND 16 CHANNEL SYSTEMS AND THE ELECTRICAL STIMULATION INTEGRATION. AIM 2 WILL BUILD UPON THE EFFORTS IN AIM 1 TO EXPAND THE SYSTEM TO UP TO 64 CHANNELS WITH 8 CHANNELS OF ELECTRICAL STIMULATION. BOTH AIMS WILL ALSO INCLUDE HARDWARE AND SOFTWARE INTEGRATION WITH THE SPIKE NEURO DATA ACQUISITION SYSTEM. AIM 3 WILL CONCLUDE WITH BENCHTOP AND IN VIVO VALIDATION OF OUR SYSTEM TO DEMONSTRATE SUCCESSFULLY ACHIEVING KEY FEATURES NEEDED FOR A COMMERCIAL WIRELESS RECORDING AND STIMULATION HEADSTAGE. THIS PROPOSAL BRINGS TOGETHER A STRONG TEAM OF EXPERTS IN WIRELESS TECHNOLOGY, ELECTROPHYSIOLOGY, AND COMMERCIALIZATION TO DEVELOP A WIRELESS SYSTEM THAT MEETS THE GROWING NEEDS OF THE NEUROSCIENCE COMMUNITY. THE PHASE I WORK WILL RESULT IN A MULTIPLE HEADSTAGE OPTIONS READY FOR COMMERCIALIZATION WHILE INFORMING CONTINUED PHASE II DEVELOPMENT. IN OUR FUTURE WORK, WE WILL CONTINUE TO SCALE OUR SYSTEM TO INCREASE CHANNEL COUNT AND REDUCE THE LATENCY OF THE CLOSED-LOOP ELECTRICAL STIMULATION.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $422.8k | 7/23/24 | ||
| Not listed | $567.3k | 8/17/23 | ||
| Not listed | $567.3k | 8/17/23 |