High-speed hyperspectral imaging for highly multiplexed immunofluorescence imaging
Ended Project Grant Awarded Last action
- Award ID
- R43MH135772
- Recipient
-
Numentus Technologies Inc. UEI HGYJGDEE8CM6
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $300,691
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date
- Originally
- Place of performance
- California, USA
Award details come from USAspending.gov.
Description
- Abstract
- Pathology using immunohistochemistry (IHC) remains a critical tool in modern clinical medicine. However, the capabilities of routine IHC methods have not kept pace with advances in biomedicine, which require evaluating networks of, e.g., tens of large molecules (typically protein targets) in a tissue context by multiplexing. To overcome this limit, highly multiplexed IHC imaging systems based on mass spectrometry and repeated immunofluorescence (if) imaging have been developed. These systems claim theoretical multiplexing of up to 100 targets. However, they are too slow, expensive, and complex, for routine use, and are currently used in a small number of research laboratories. We are working to radically change the capabilities of if imaging to allow routine detection of tens of molecular targets rapidly and at moderate cost. Our approach builds on our previous work on high-speed hyperspectral imaging coupled with amplified molecular target labeling methods. We will advance our technology and demonstrate its capabilities with a specific research application involving imaging of brain sections from a mouse model of a neuropathology relevant for alzheimer's disease (ad). We will make improvements to achieve simpler and faster operation of our technology. We will then image up to 12 targets and demonstrate the ability to extend our approach to tens of targets on a single tissue slide. We expect our instrumentation and protocols will be sufficiently simple, low cost, and rapid to allow routine use in most pathology and research laboratories. !
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $300,691 |
Quick answers
Who received award R43MH135772?
R43MH135772 was awarded to Numentus Technologies Inc. by National Institute of Mental Health (National Institutes of Health) on September 1, 2023.
How much is award R43MH135772 worth?
$300,691 has been obligated on R43MH135772.
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