Next generation axonal quantification and classification using AI
Ended Project Grant Awarded Last action
- Award ID
- R43MH128076
- Recipient
-
Microbrightfield, LLC UEI L5XGENY3LNN7
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,514,451
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date
- Funding
-
- $1,064,634.00 Federal
- $449,817.00 Non-federal
- Place of performance
- Vermont, USA
Award details come from USAspending.gov.
Description
- Abstract
- This lab to marketplace project describes the development of hyperaxon™, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers visible in three-dimensional (3D) microscopic images of central nervous system (CNS) areas, even those with extremely high axonal fiber density. Accurate and rigorous analysis of all axonal fibers visible in 3D microscopic images of CNS tissue of non-transgenic and transgenic animal models as well as in human post mortem CNS tissue holds the promise of novel insights into physiological neural network connectivity patterns as well as into the neuropathological underpinnings of alterations in connectivity associated with human neuropsychiatric and neurological disorders. However, this cannot be achieved with contemporary, computer-assisted tracing and reconstruction methods, which currently are the gold standard for investigating axonal fibers, because these methods primarily address tracing and reconstruction of only a limited number of individual axonal fibers. Hyperaxon will be based on the highly innovative artificial intelligence technology learning-based tracing of dense axonal fibers (ltdaf) that was recently developed at MIT lincoln laboratory (MIT LL) (lexington, MA). This project will build upon the original, lab-built ltdaf technology to create commercial software for wide- spread dissemination of this important new technology. Dissemination of this technology via a lab to marketplace commercial product is consistent with nimh goals and will result in the technology having a significant impact on neuroscience research. The game-changing innovation in hyperaxon is the ability to automatically (i) segment, trace and reconstruct all axonal fibers visible in 3D microscopic images of CNS areas with high axonal fiber density, (II) identify axonal branch points, (III) resolve axonal fibers of passage from axonal fibers that make presumptive synapses in target regions, (IV) identify axonal fibers showing acute axonal injury and (v) precisely quantify alterations in number and density of axonal fibers in CNS tissue. Based on published pilot work performed at MIT LL, we are convinced that hyperaxon will be impactful in the field of neuroscience research and will enable substantial advancements in research on alterations in CNS circuitry associated with neurodevelopmental, neuropsychiatric, neurodegenerative and neurological disorders. Ultimately, this will result in an improved basis for developing novel treatment strategies for a wide spectrum of complex brain diseases. In phase i we will demonstrate feasibility of this novel technology by developing prototype software; work in phase II will focus on creating the full functionality of hyperaxon for commercial release. We will perform extensive feasibility studies, product validation and usability studies of hyperaxon in close collaboration with MIT LL and our academic collaboration partners. A competing technology is not available.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $55,000 | $0 | |
| Amendment | $55,000 | $0 | |
| Amendment | $55,000 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $449,817 | $0 | |
| Original award | $449,817 | $449,817 |
Show all 16
Quick answers
Who received award R43MH128076?
R43MH128076 was awarded to Microbrightfield, LLC by National Institute of Mental Health (National Institutes of Health) on April 1, 2022.
How much is award R43MH128076 worth?
$1,514,451 has been obligated on R43MH128076: $1,064,634 in federal funding and $449,817 in non-federal funding.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award