Cooperative Agreement R43IP001127

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $400,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Baylor College of Medicine in Houston, Texas. The funding will support pre-clinical studies to test the prophylactic efficacy of a potential vaccine against extraintestinal pathogenic E. coli (ExPEC), a member of the human microbiome that has become a leading cause of antibiotic-resistant mortality worldwide. The research...

This Project Grant award of $709,236 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop a nanoparticle-based adjuvant formulation containing a TLR7 agonist to overcome immunodominance and induce broad antibody responses against the influenza virus. The primary research goals are to: 1) Determine how the TLR7 nanoparticle adjuvant impacts immunodominance, breadth, and tolerance across...

The University of Missouri System, under a $650,000 project grant from the USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program, is developing safe and effective live attenuated swine influenza vaccines using Newcastle disease virus (NDV) as the vector. The project aims to address the challenges with current swine influenza vaccines, which often fail to provide cross-protection against diverse virus strains. The key products and...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded Orlance, Inc., a woman-owned small business, a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an enhanced seasonal influenza DNA vaccine. The project aims to combine the advantages of a closely matched seasonal influenza vaccine with a universal influenza vaccine to provide more robust and durable protection, especially for the elderly and immunocompromised...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $185,513 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Tulane University to develop a multivalent subunit vaccine against enterotoxigenic Escherichia coli (ETEC), one of the major causes of diarrheal disease in children in low-resource settings. The project aims to test the hypothesis that immunization with outer membrane vesicle (OMV)-adjuvanted vaccines containing ETEC antigens, including...

This federal Project Grant award from the United States Department of Agriculture's National Institute of Food and Agriculture, under the Agriculture and Food Research Initiative (AFRI) CFDA 10.310 program, provides $648,881 to the University of Maryland, College Park to develop a mucosal vaccine for influenza that can prevent initial and recurrent infections and reduce transmission between animals and humans. The goal is to create a universal influenza vaccine delivered through a nasal spray...

The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $13,946,446 Cooperative Agreement titled "PROVIDENT: PREPOSITIONING OPTIMIZED STRATEGIES FOR VACCINES AND IMMUNOTHERAPEUTICS AGAINST DIVERSE EMERGING INFECTIOUS THREATS" to the Albert Einstein College of Medicine. The overarching goal of this 5-year project is to deliver "plug-and-play" vaccine and therapeutic antibody...

This $649,896 Project Grant award from the U.S. Department of Agriculture's (USDA) Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310) will support research to develop an mRNA-based influenza vaccine for livestock. The project aims to create a vaccine cocktail containing mRNA encoding a chimeric hemagglutinin (HA) antigen with conserved HA stalk domains, along with an H5 antigen from highly pathogenic avian influenza (HPAI) H5N1. This vaccine will be delivered using a novel...

The University of Delaware will conduct research on exosomes and their role in Marek's disease virus vaccination under a $650,000 US Department of Agriculture National Institute of Food and Agriculture Agriculture and Food Research Initiative award. The objectives are to identify how exosomes from vaccinated chickens stimulate immune cells and determine if exosomes alone or in combination with vaccines can enhance protection against Marek's disease virus challenge. The researchers will also...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $548,802 to Ancilia Biosciences Inc. to enhance the colonization of the probiotic E. coli Nissle 1917 strain using CRISPR-Cas immunity. The goal is to improve the therapeutic efficacy of live biotherapeutic products (LBPs) for treating inflammatory bowel disease (IBD) by addressing...