Project Grant R43HL184887
- The National Cancer Institute awarded Tiba Biotech LLC $399,300 on September 10, 2025, under the Cancer Treatment Research program (CFDA 93.395) to develop targeted delivery of enhanced self-amplifying RNA encoding tumor antigens to the spleen for cancer immunotherapy. Tiba Biotech will combine proprietary enhanced self-amplifying RNA (esRNA) technology with spleen-targeting biodegradable nanoparticles based on molecularly defined dendritic structures to deliver tumor antigen to...
- The National Institutes of Health National Heart Lung and Blood Institute awarded Brigham & Womens Hospital Inc. $1,242,222 on March 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate non-coding RNAs as therapeutic targets in chronic limb-threatening ischemia. The funded research addresses the pathophysiology of chronic limb-threatening ischemia (CLTI), a leading cause of amputation in adults affecting over 200 million people globally. The project will...
- The National Heart, Lung, and Blood Institute awarded The University of North Texas Health Science Center at Fort Worth $426,550 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a bioengineering modular gene delivery system for lung-targeted transgene expression. The project addresses systemic gene therapy for monogenic lung diseases including cystic fibrosis, alpha-1-antitrypsin deficiency, and pulmonary arterial hypertension. The recipient...
- The National Heart, Lung, and Blood Institute awarded $799,998 to The Trustees of the University of Pennsylvania on August 12, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiotropic solid lipid nanoparticles (LNPs) as a drug and biologic delivery platform for cardiac therapeutics. The research focuses on engineering and understanding heart-targeting LNPs that accumulate in cardiac tissue at significantly higher concentrations than existing drug delivery...
- The National Heart, Lung, and Blood Institute awarded Emmune Inc. $299,664 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a non-viral gene therapy vector for treating and preventing atherosclerotic cardiovascular disease. Emmune will leverage lipid nanoparticle (LNP) technology to achieve non-immunogenic gene delivery of a therapeutic protein capable of treating and preventing atherosclerosis. The company has discovered a novel approach to...
- The National Heart, Lung, and Blood Institute awarded Cmtx Biotech Inc. $367,988 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a lung-specific, sulfonium lipid nanoparticle formulation of Incyclinide (CMT-3/SLNP) for treating acute respiratory distress syndrome in sepsis patients. This Phase I Small Business Technology Transfer project will evaluate the formulation and delivery of CMT-3/SLNP, a chemically modified, non-antibiotic tetracycline...
- The National Heart, Lung, and Blood Institute awarded Coridea, LLC $305,365 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cooled radiofrequency bronchoscopic lung volume reduction technology for severe emphysema patients. The project addresses a clinical gap in lung volume reduction therapy. Current surgical options reach only a fraction of severe emphysema patients: wedge excision LVR surgery is invasive and limits candidate eligibility, while...
- The National Heart, Lung, and Blood Institute awarded Nytricx, Inc. $314,337 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to engineer nitric oxide-releasing intravascular catheters with solid slippery surfaces designed to combat infection and thrombosis in short-term applications. Nytricx, Inc., a self-certified small disadvantaged business headquartered in Athens, Georgia, specializes in nitric oxide release polymer technologies for advanced medical...
- The National Heart, Lung, and Blood Institute awarded Cedars-Sinai Medical Center $300,000 on July 8, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to support therapeutic preclinical development of TY1, a novel synthetic noncoding RNA drug candidate for scleroderma heart disease. The award funds investigation of TY1's mechanisms in reversing cardiac fibrosis associated with systemic sclerosis, a lethal autoimmune complication. TY1 is a 24-nucleotide chemically-modified...
- The National Heart, Lung, and Blood Institute awarded Texas A&M Engineering Experiment Station $405,966 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a multifunctional nanoparticle platform targeting galectin-3 for pulmonary fibrosis therapy. The recipient will optimize anti-fibrotic drug-containing, galectin-3-targeted poly(lactic-co-glycolic acid) nanoparticles for pulmonary delivery, building on prior results demonstrating nanoparticle...
The National Heart, Lung, and Blood Institute awarded Tiba Biotech LLC $396,805 under the Cardiovascular Diseases Research program (CFDA 93.837) on August 1, 2026, for development of lung-targeting delivery systems for small interfering RNA therapeutics. Tiba Biotech is advancing a proprietary non-viral RNA delivery platform called RNABL, which employs dendritic aminoalkyl-branched lipidoids as nanoparticle carriers. The platform addresses a critical gap in nucleic acid therapeutics: achieving targeted tissue delivery with minimal off-target effects and reduced inflammatory burden. Current systemically administered RNA interventions are largely hepatotropic; lung delivery remains particularly challenging despite clinical need for treatments of acute respiratory distress syndrome, pulmonary hypertension, and pulmonary fibrosis. Tiba's approach positions itself as an alternative to lipid nanoparticles, enabling formulation for surgical-precision payload delivery to specific tissues and cells. Work is performed in Woburn, Massachusetts, with a period of performance from August 1, 2026, through July 31, 2027. This is a Phase I Small Business Innovation Research award, part of NHLBI's commitment to stimulating technological innovation through competitive awards to small businesses and fostering private-sector commercialization of federal R&D innovations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $396.8k | 8/3/26 |