Project Grant R43HL184803
- The National Heart, Lung, and Blood Institute awarded Lynntech Inc. $319,607 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and demonstrate the feasibility of BreathWise, an AI-driven early-warning system for COPD exacerbations. BreathWise integrates multimodal physiological, behavioral, and environmental sensing with machine learning-based predictive analytics to identify COPD patients at imminent risk of exacerbation. The system continuously...
- The National Heart, Lung, and Blood Institute awarded $316,609 to Remplenish, Inc. on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a novel myofunctional nipple device for preventing obstructive sleep apnea in infants. The recipient will design and validate a low-risk, low-burden device that delivers myofunctional therapy—oropharyngeal exercises integrated into infant bottle feeding—as a non-invasive first-line treatment and preventive measure...
- The National Institute of Environmental Health Sciences awarded Spiromatics, Inc. $471,544 on September 16, 2025, under the Medical Library Assistance program (CFDA 93.879) to develop a portable, handheld spirometer equipped with audiovisual coaching for improved detection and monitoring of obstructive lung disease. Spiromatics is developing novel diagnostic methods and a patient-friendly measurement approach that detects airflow limitation in approximately 11 percent more individuals than...
- The National Heart, Lung, and Blood Institute awarded Actiox LLC $699,468 on September 10, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) for development of a wearable microneedle-based biosensor for continuous cardiac troponin I monitoring. The assistance type is a Project Grant. Actiox will develop and optimize an electrochemical aptamer-based sensor integrated with microneedle arrays capable of real-time, ultra-sensitive monitoring of cardiac troponin I in interstitial...
- The National Heart, Lung, and Blood Institute awarded Nightingale Labs Corp $1.368 million on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to commercialize non-contact cardiopulmonary monitoring technology for heart failure management. Nightingale Labs is developing a fully automated, non-contact home bed sensor platform that monitors cardiopulmonary physiology without requiring active patient participation, aimed at detecting clinical deterioration in heart...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $197,634 in project grant funding on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). This K23 mentored research award funds investigation of inhaled nitric oxide (INO) responder and non-responder phenotypes in persistent pulmonary hypertension of the newborn (PPHN) using electrical impedance tomography (EIT)...
- The National Heart, Lung, and Blood Institute awarded Cincinnati Children's Hospital Medical Center $331,340 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate dynamic free-breathing 129Xe MRI as a non-invasive functional lung imaging tool for pediatric populations including neonates, infants, toddlers, and young children. The project addresses limitations of current clinical assessment methods for pediatric lung diseases such as...
- The National Heart, Lung, and Blood Institute awarded Nytricx, Inc. $314,337 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to engineer nitric oxide-releasing intravascular catheters with solid slippery surfaces designed to combat infection and thrombosis in short-term applications. Nytricx, Inc., a self-certified small disadvantaged business headquartered in Athens, Georgia, specializes in nitric oxide release polymer technologies for advanced medical...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of North Carolina at Chapel Hill $420,281 on April 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to design, fabricate, and test a needle-type nitric oxide sensor in a swine model as a function of diabetes disease state. The project will establish the analytical performance of implantable nitric oxide sensors with robust...
- The National Heart, Lung, and Blood Institute awarded Linshom Medical, Inc. $322,277 on September 10, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct clinical evaluation of an alarm-activated detection system for early intervention of emerging respiratory decline using Linshom's FDA-cleared Continuous Predictive Respiratory Sensor (CPRS). The funding supports clinical development activities demonstrating the health economic value of the CPRS system, which...
The National Heart, Lung, and Blood Institute awarded $591,499 to Giner, Inc. on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837, SBIR Phase I mechanism R43HL184803) to develop a portable, low-cost fractional exhaled nitric oxide (FeNO) breathalyzer for home-based asthma monitoring in children aged six and older. The device integrates a compact electrochemical nitric oxide sensor, humidity control module, and Bluetooth-enabled smartphone interface to enable children and caregivers to measure FeNO levels at home and transmit data to clinicians for remote monitoring. Phase I work focuses on building and validating a handheld prototype using the Alphasense NO-B4 sensor, developing the humidity control system, and creating real-time signal processing algorithms. The prototype will be evaluated in a clinical study with pediatric asthma patients at Boston Children's Hospital. The innovation addresses barriers to routine FeNO testing by providing user-centered, maintenance-free operation designed specifically for pediatric use, supporting early detection of airway inflammation and timely therapy adjustments. Performance of work occurs in Auburndale, Massachusetts, with a period of performance from September 1, 2026, through August 31, 2027. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $591.5k | 9/1/26 |