This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $656,751 to Third Coast Dynamics, Inc. to develop an artificial intelligence-based platform called "TCDFLOW" that can derive 4D hemodynamic data from routine clinical anatomic images. This will address limitations of current 4D flow MRI techniques, which require specialized equipment and expertise, by enabling the...
This federal Project Grant award from the Department of Defense's Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $3,984,239.00 to Microvascular Therapeutics Inc. to conduct IND-enabling studies for targeted phase shift microbubbles for sonothrombolysis. The funding supports research and development activities by the for-profit biotechnology company to advance ultrasound contrast agent and delivery system technologies for diagnostic and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $767,077 to the University of North Carolina at Chapel Hill (UNC-CH) to validate and extend a bioengineering platform technology for the delivery of protein-based drugs, including thrombolytic enzymes. The proposed research seeks to address key issues such as accommodating different thrombolytic proteins, achieving multi-drug...
This $413,595 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Program (CFDA 93.837), supports the development of a magnetic rotational atherectomy platform to address challenging coronary lesions. The funded effort aims to create an over-the-wire atherectomy device that utilizes magnetic fields to safely rotate a burr at lower speeds, reducing risks associated with the high-speed rotational atherectomy and orbital...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) provides $199,930 to the University of Chicago to assess microbubble-induced stresses on soft materials like tissue, in order to support the development of regulatory guidelines for bubble-based medical devices like therapeutic ultrasound systems. The key objectives are to: 1) develop and characterize a mechanophore-based tissue phantom to quantify microbubble-induced deformation, 2)...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $443,544 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to Dasisimulations LLC, a minority-owned small business located in Dublin, Ohio. The grant supports the development and validation of an innovative, AI-driven software platform to automatically perform complex measurements for pre-planning transcatheter aortic valve replacement (TAVR) procedures. The project aims to (1) develop and validate the...
This federal Project Grant award of $200,557 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program aims to develop and validate a novel ultrasound imaging technology for high-contrast, high-resolution microvascular imaging. The key products to be delivered under this 2-year project include: 1) design and implementation of a duplex dual-frequency 1D...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $666,609 to North Carolina State University to develop and demonstrate the feasibility of lung quantitative ultrasound (LQUS) for assessing the severity of pulmonary edema due to heart failure and idiopathic pulmonary fibrosis. The goal is to create a real-time, non-invasive, point-of-care method to monitor these lung conditions,...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to develop an AI-augmented, image-based hemodynamic modeling platform to enhance cardiovascular research and healthcare. The $150,000 award, effective September 1, 2024 through May 31, 2028, will be used by the University of Notre Dame to automate the transformation of medical images into 3D geometries for computational fluid...
This $647,359 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the engineering of biomaterials with controlled biomolecule delivery for cardiovascular applications. The key products and services to be delivered include: Efficient and sustainable delivery of microRNA-145 from a novel biomaterial (PVA-CDI immobilized aminated fucoidan, or PCAF) to smooth muscle cells to induce a contractile...
This Project Grant award of $618,912, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a biophysics-based numerical platform for accurately characterizing microbubble-enhanced ultrasound and its interaction with blood clots. The platform will enable predicting clot lysis rates under various operating conditions to accelerate and promote the clinical applications of microbubble-enhanced sonothrombolysis, a non-invasive ultrasound treatment for thrombosis. The awardee, Dynaflow, Inc., a minority-owned small disadvantaged business, will leverage their expertise in advanced fluid dynamics modeling and high-performance computing to overcome technical challenges and deliver an efficient, accurate simulation tool. This project has the potential to significantly benefit public health by reducing risks and enhancing the efficiency of conventional sonothrombolysis treatments.