Project Grant R43HL150991

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $229,971 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of North Carolina at Chapel Hill (UNC-CH) to develop and test novel hydrogel patches that can prevent air leaks after lung surgery. The goal is to eliminate the need for chest tubes following lung resection procedures, which would reduce complications, costs, and improve patient quality of life. The project involves optimizing the hydrogel...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports the continued clinical development of a novel pleural and tracheal sealant. The $381,000 award to the University of Vermont will fund research to: 1) define optimal manufacturing, sterilization, and storage conditions for the sealant patch; 2) further evaluate the long-term safety and efficacy of the sealant in animal models...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is funding the development and testing of a "VentSafe" bidirectional synchronous flow-controlled ventilation system to improve oxygenation and ventilation in Acute Respiratory Distress Syndrome (ARDS). The $1,160,157 award to Liberandum Technologies, Inc. aims to design a ventilation system with lower potential for trauma and reduced...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $842,408 to Inspire RX LLC to develop and evaluate the Aerosolve Biohelmet. The Aerosolve Biohelmet is a personal negative pressure device designed to safely transport and treat patients with highly transmissible respiratory illnesses, including COVID-19, influenza, tuberculosis, and measles. The project aims to refine the Biohelmet...

This $256,000 National Science Foundation project grant supports the development of an automated chest tube to prevent clotting. Circulatech LLC will design and prototype a novel chest tube that proactively manages fluid flow within the catheter lumen to flush and drain the tube, reducing blood clot formation. Through a process called "dilutional coagulopathy," the tube will use sterile saline or anticoagulants to reduce thrombosis in the drainage space rather than relying on...

This federal Project Grant award of $805,845 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development and testing of novel lung-targeted therapeutic delivery systems. The goal is to create "precision drug delivery systems" that can actively transport anti-fibrotic agents directly into lung tissue to treat conditions like idiopathic pulmonary fibrosis. Key products/services include engineering...

This Project Grant award, with a total funding of $5,963,305.00, was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) for the continued clinical development of a novel pleural and tracheal sealant. The primary award recipient is the University of Vermont & State Agricultural College. A sub-award of an unspecified amount was provided to the University of Connecticut Health Center to support this research effort. The funding will...

This $8.7 million project grant from the Department of the Army Medical Command, under the Military Medical Research and Development program (CFDA 12.420), supports the development of patient care technologies for permanent ambulatory artificial lung support from May 2022 to April 2026. Carnegie Mellon University is the primary awardee and will develop technologies to transition a pulmonary assist system to long-term support of chronic lung disease patients. Vanderbilt University Medical...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $295,924 to Convergent Engineering, Inc. to develop a prototype decision support system for personalized mechanical ventilation care. The system aims to simplify the use of esophageal pressure measurements to optimize ventilator settings and prevent complications for ventilated patients. The project has two key objectives: 1) Building a...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop and test a drug-eluting chest tube to locally manage the pain associated with its use in cardiothoracic surgeries. The $275,752 award supports two key objectives: 1) completing GMP/GLP studies on the drug release kinetics, stability, and manufacturing of the drug-releasing chest tube; and 2) evaluating the mechanical...