Project Grant R43HL147793

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), CFDA Program #93.350, provides funding of $489,500 to The Children's Hospital of Philadelphia (CHOP) Research Institute to conduct research on a potential treatment for Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM). The research aims to study the effects of a small compound called Repsox on correcting the platelet defects and reducing the risk of leukemic transformation in...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $693,423 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Baylor College of Medicine. The grant will fund the development and validation of a disposable microfluidic device capable of efficiently purifying platelets for pediatric and neonatal transfusions. The project aims to optimize the Controlled Incremental Filtration (CIF) technology to remove contaminants from platelet units while preserving...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $295,895 to Ricovr Healthcare Inc. to develop a novel point-of-care diagnostic platform for quantitatively measuring placental growth factor (PLGF) levels. The goal is to create an affordable, sensitive, and objective tool for predicting and detecting pre-eclampsia, a serious gestational hypertension condition affecting up to 8% of...

This $225,600 project grant awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to engineer a lab-on-a-particle platform to measure platelet function. The project will synthesize peptide-functionalized hydrogel microparticles to serve as individual test sites for studying platelet adhesion, activation, aggregation, and contraction. The research will utilize immobilized and suspended particle assays to measure...

The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...

This $550,000 Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development and validation of a non-invasive, multiplex blood test for the early detection of preeclampsia, a serious pregnancy complication. The project aims to advance the detection of vascular dysfunction, particularly preeclampsia, by optimizing a blood test that targets disease-inducing signaling proteins on the surface of...

This Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) provides $178,000.00 to Boston Children's Hospital to develop a bone marrow organoid system to study the rare genetic disorder RUNX1-Familial Platelet Disorder with Associated Myeloid Malignancy (RUNX1-FPD/MM). The 1-year project aims to generate bone marrow organoids from patient-derived induced pluripotent stem cell lines, both with and without the RUNX1 genetic mutation, to recapitulate the...

This $670,147 Project Grant awarded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) supports research to improve the clinical sensitivity of circulating tumor DNA (ctDNA) liquid biopsies for cancer detection and monitoring. The overarching goal is to increase understanding of the molecular mediators regulating cell-free DNA (cfDNA) biogenesis and release, with the aim of developing new approaches to enhance ctDNA detection. The...

This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a non-invasive liquid biopsy screening tool for detecting the causes and consequences of preterm birth. The $717,871 award, granted to the Magee-Womens Research Institute and Foundation, will fund the development of epigenomic analytical methods to predict the clinical trajectories of...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $139,446 to the Mayo Clinic to evaluate the mechanisms by which cell-free fetal DNA (cfDNA) signaling promotes labor and parturition. The key objectives are to: 1) Determine if inhibiting the cGAS/STING pathway can reduce CD14+ monocyte activation and the pro-inflammatory cascade following...