Project Grant R43HL130814

This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...

Rattan Life Science Inc. received a $275,000 Project Grant award from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a platform for generating induced pluripotent stem cell-derived naïve CD4+ and CD8+ T cells with fidelity, reproducibility and scalability. The platform employs proprietary induced thymic epithelial cells to provide biologically relevant thymic positive selection signals during T cell differentiation,...

This $250,000 National Science Foundation Technology, Innovation, and Partnerships Project Grant supports the development of artificial substrates for growing human stem cells suitable for clinical applications at Oakland University from March 2023 to February 2025. The goal is to accelerate the potential benefits of using human pluripotent stem cells and their derivatives for treating and curing diseases by producing a synthetic substrate that supports growth of human pluripotent stem cells...

This National Science Foundation Project Grant of $100,000 supports research into polyelectrolyte multilayered surfaces for use in human mesenchymal stem/stromal cell manufacturing. The goal is to develop a scalable and controllable polymeric coating composed of natural polymers to improve the cell expansion process used in producing therapeutic human mesenchymal stromal cells. The coating is constructed via layer-by-layer assembly of collagen and heparin and has been shown to increase cell...

Federal Grant Award Summary The Washington University received a $427,625 Project Grant (R21) from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded May 1, 2026, with completion targeted for April 30, 2028. The grant funds development of an integrated biomanufacturing and cryopreservation platform designed to enable scalable, clinical-grade production of human induced pluripotent stem cell (hiPSC) therapies. The project addresses critical bottlenecks in stem...

This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...

This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of...

This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $305,000 to Cellecho, Inc. to develop a microchip-based technology for advanced cell engineering. The goal is to create a miniaturized liquid and cell handling platform that leverages acoustic-electric micro-vortices to precisely and sequentially deliver genetic molecules. This innovation aims to make complex cell reprogramming more...

This $1,000,000 National Science Foundation project grant supports research at the University of Wisconsin-Madison to develop single cell-level programming of human induced pluripotent stem cell differentiation into chamber-specific cardiomyocytes. The goal is to generate cardiomyocytes from each chamber of the heart through precise control of Wnt and retinoic acid signaling at the single cell level via engineered genetic programs and superstructures. If successful, this approach could establish...

This Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems Engineering Directorate will support $541,665 in research at The University of Iowa from October 2022 through September 2026. The grant aims to advance control of human induced pluripotent stem cell differentiation to retinal cells through genomic and microfluidic techniques. Researchers will develop genome-wide methods leveraging cell differentiation properties...