Project Grant R43HD122546
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded San Francisco State University $200,000 on July 1, 2026, under the Engineering Research Initiation (ERI) program (CFDA 47.041) to investigate the fallopian tube's shape and physical environment to improve embryo culture for fertility treatment. The project will create quantitative three-dimensional reconstructions of the inner passage of the human fallopian tube by processing nine micro computed...
- The National Center for Advancing Translational Sciences awarded CFD Research Corporation $349,752 on August 17, 2026, under NCATS' translational science grant program (CFDA 93.350, NCATS program). The award funds development of the High-Throughput Organoid Platform for Electrophysiology Studies (HOPES)—an integrated, automated system for growing, maintaining, and screening brain organoids at high throughput using multi-electrode array (MEA) technology embedded in a microphysiological system...
- This National Science Foundation (NSF) Project Grant award of $275,000 to Zealous Research LLC is part of the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to develop a single-chip microfluidic platform to automate and optimize in vitro fertilization (IVF) processes, including sperm selection, sperm capacitation, and egg fertilization. The goal is to create a user-friendly, affordable, and high-throughput platform that can increase IVF success rates and...
- The National Institute of Child Health and Human Development awarded PS-Fertility, Inc. $356,502 on September 15, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop PS-DETECT, a diagnostic assay for male fertility and infertility assessment. PS-DETECT uses phosphatidylserine as a biomarker to quantify fertilization-competent sperm in ejaculate, addressing a gap in conventional semen analysis that clinicians view as providing limited functional...
- The National Institute of Child Health and Human Development awarded Worcester Polytechnic Institute $555,371 on June 1, 2026, to develop bioengineered in vitro models of uterine fibroids under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funded work creates two novel in vitro platforms—one with tunable transport properties and one modeling intramural uterine fibroids surrounded by myometrium—to study how altered signaling from sex hormones (estrogen...
- The National Institute of Child Health and Human Development (NICHD), a component of the Department of Health and Human Services National Institutes of Health, awarded $148,994 to the University of Wisconsin System (operating through its University of Wisconsin - Madison Division) on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, assistance type Project Grant F31HD119998). The recipient will conduct research investigating the role of the...
- The National Institute of Child Health and Human Development awarded Oregon Health & Science University $826,077 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate CFTR inhibition as a nonhormonal contraceptive approach. The research project examines how blocking the cystic fibrosis transmembrane conductance regulator (CFTR) in cervical cells increases mucus viscosity, rendering it impenetrable to sperm. The investigator's...
- The National Institute of Child Health and Human Development (NICHD) of the Department of Health and Human Services awarded North Carolina State University $673,394 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to decode epigenetic networks that orchestrate endometrial function. The project addresses molecular mechanisms underlying uterine dysfunction in recurrent implantation failure and recurrent pregnancy loss, which remain major...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- The National Institute of Child Health and Human Development awarded the University of Toledo $448,793 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate spermatozoa head-kinking mechanics and their role in male fertility. The research addresses molecular and cellular mechanisms underlying human spermatozoa navigation and egg fertilization. The project will employ rabbits as a genetic model and high-resolution microscopy to...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded $180,000 to CFD Research Corporation on September 5, 2026, under the National Center for Advancing Translational Sciences program (CFDA 93.350) to develop FERTILICHIP, an innovative fallopian tube-on-chip microfluidic model for women's reproductive health research. FERTILICHIP will be the first comprehensive, vascularized human fallopian tube in vitro model system incorporating four key cell types—secretory epithelial cells, ciliated epithelial cells, lamina propria fibroblasts, and smooth muscle cells—under physiological conditions. The platform will enable research on sexually transmitted infection-triggered pelvic inflammatory disease progression, biomarker discovery, therapeutic development, host-pathogen interactions, and hormonal responses. The model will use polydimethylsiloxane-based microfluidic devices with primary fallopian tube epithelial cells differentiated using estradiol. The project addresses a gap in current in vitro and animal models, which lack cellular complexity, physiological flow conditions, and human anatomical accuracy, while aligning with federal agency calls to reduce animal testing in favor of new approach methodologies. Performance occurs in Huntsville, Alabama from September 5, 2026, through September 4, 2027. CFD Research, a small business headquartered in Huntsville, will self-perform the work. The assistance type is Project Grant, classified as a Phase I Small Business Innovation Research grant (R43).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $180.0k | 9/3/26 |