Project Grant R43GM165235
- This $769,749 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences will support the development of Fluorescence Enhanced Photothermal Infrared Spectroscopy (FE-PTIR) technology by Photothermal Spectroscopy Corp. The FE-PTIR technique aims to provide simultaneous fluorescence microscopy and sub-micron infrared spectroscopy to map the distribution of fluorescently labeled biomolecules within cells and tissues while also analyzing their chemical...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded 37Degrees, Inc. $360,247 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type: Project Grant). The award funds development of photoacoustic microscopy systems for non-destructive, three-dimensional imaging of live and incubated engineered tissue. The project addresses a critical gap in...
- The National Institute of General Medical Sciences awarded N.p. Photonics, Inc., a Tucson, Arizona-based small business, $306,873 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to develop a low-cost robust compact 900 nanometer femtosecond laser source for two-photon microscopy, featuring ultrashort pulse lasers with peak powers exceeding 1 kilowatt and specified pulse durations. The award obligates $306,873 and runs through August 31, 2027,...
- The National Institute of Standards and Technology (NIST) awarded a $283,489.89 Cooperative Agreement grant to Photothermal Spectroscopy Corp. under the CHIPS Research and Development (CFDA 11.042) program. The purpose of the grant is for Photothermal Spectroscopy Corp. to develop, validate, and commercialize a new "Gigahertz Optical Photothermal Infrared" instrument for the semiconductor industry. This instrument will enable high-speed thermal properties analysis and simultaneous...
- The National Institute of General Medical Sciences awarded Third Floor Materials, Inc. (3FM) $298,111 on September 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a high-throughput snapshot hyperspectral imager for multiplexed fluorescence microscopy. The system combines proprietary plasmonic filter arrays with backside-illuminated CMOS sensors to enable capture of complete hyperspectral datacubes—containing both spectral and spatial...
- The National Institute of General Medical Sciences awarded Physical Sciences Inc. $311,847 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a fluorescence-based rapid phage detection system for industrial bioreactors. Physical Sciences Inc. and the University of Connecticut are developing a lyobead assay platform that detects bacteriophage contamination in bioreactor systems within hours. The system uses a sampling chamber loaded with...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $1,830,401 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop plasmonic enhanced Raman structured illumination microscopy (PERSIM), a novel microscopy technique designed to improve resolution and sensitivity in label-free molecular imaging. PERSIM combines localized plasmonic structured illumination microscopy with Raman scattering microscopy to...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $232,550 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a mid-infrared photothermal fiber probe for label-free imaging and biomolecular composition analysis in endoscopic applications. The project will develop a fiber-based probe that integrates mid-infrared photothermal imaging with...
- The National Institute of General Medical Sciences (NIGMS) awarded The Salk Institute For Biological Studies $475,249 on August 10, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to develop photon-efficient spectral lifetime microscopy technology. The award funds development of optical technology for multiplexed fluorescence imaging that combines fluorescence lifetime and spectral imaging approaches to increase the dimensionality of fluorescent signals. The...
- The National Institute of General Medical Sciences awarded Epitune LLC $350,000 on September 16, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an imaging-based platform for single-cell analysis of human-induced pluripotent stem cell identity. The platform combines microscopic imaging of epigenetic landscape, advanced image analysis, picowell arrays, and fluidic devices to enable rapid, affordable assessment of hiPSC identity at single-cell resolution....
The National Institute of General Medical Sciences awarded Photothermal Spectroscopy Corp. $306,802 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a next-generation photothermal stimulated Raman scattering (PT-SRS) microscope for high-speed, label-free chemical imaging of live cells in standard multiwell culture plates. Current PT-SRS implementations use transmission geometries that prevent compatibility with inverted microscopes and 96-well plate formats standard in modern cell biology. Photothermal Spectroscopy will demonstrate feasibility of the first epi-detected PT-SRS platform on an inverted microscope, eliminating the need for specialized substrates or complex sample handling. The approach integrates three co-aligned beams (pump, Stokes, and probe) with optimized detectors to achieve robust sensitivity, high spatial resolution, and biologically safe power levels. Specific Aim 1 will establish technical feasibility by assembling the optical system, validating pointing stability, and characterizing sensitivity, resolution, and signal-to-noise using chemical standards and calibration beads. Specific Aim 2 will demonstrate biological feasibility by acquiring lipid and protein vibrational images of live cells in 96-well plates. The award is classified as a Phase I Small Business Innovation Research (SBIR) project grant. Performance occurs in Santa Barbara, California, with a period of performance from September 1, 2026, through August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.8k | 8/27/26 |