Project Grant R43GM165185
- Federal Grant Award Summary The University of Colorado received a $2.11M Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with a completion date of August 31, 2029. The project focuses on developing and deploying readily deployable technology for reproducible cryogenic sample time-resolved electron microscopy (CryoTREM). The primary deliverable is a patterned...
- Federal Project Grant Award Summary Molecular Instruments, Inc. received a $306,788 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) with an award date of September 30, 2025, and a completion date of September 29, 2026. The award supports the development and advancement of probe technology for ultrasensitive RNA imaging utilizing Hybridization Chain Reaction (HCR) methodology. The project...
- Federal Grant Award Summary Intellicule LLC received a $435,882 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through February 28, 2027. This Small Business Innovation Research (SBIR) Phase I project will develop advanced software tools for structure and ligand modeling that enable accurate visualization of drug-receptor interactions from cryo-electron...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded The Trustees of Columbia University in the City of New York a $1,200,000 Project Grant on March 15, 2025 to develop and apply a method of time-resolved cryo-electron microscopy (cryo-EM) to diverse biological molecules of medical importance. The project aims to use newly designed PDMS-based microfluidic chips to apply the time-resolved cryo-EM sample preparation technique, which has been...
- The Department of Energy Office of Science awarded a $250,000 Project Grant to Hummingbird Precision Machine Co. of Lacey, WA to develop an ultra-stable and repeatable stage for enabling transmission electron microscopes with improved biomolecular structure characterization capabilities. The grant was awarded on February 22, 2021 under the Office of Science Financial Assistance Program (CFDA #81.049) to complete the project by November 21, 2021. The Office of Science's mission is to deliver...
- Federal Grant Award Summary QuantumBio Inc. received a $508,364 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), with an award date of September 30, 2025 and completion date of May 31, 2026. The grant funds development of a unified X-ray crystallography and cryogenic electron microscopy (cryo-EM) computational toolkit designed to improve structural refinement of protein-ligand...
- Federal Project Grant Award Summary Vivid Bioinnovations, PBC (operating as Fluid Discovery, Inc.) received a $306,872 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period August 1, 2025 through July 31, 2026. The award supports development of a commercial prototype for an ultrahigh-throughput biocatalyst evolution platform that combines precision nanoliter fluid handling, label-free...
- The National Institute of Standards and Technology (NIST) awarded a $963,000 Project Grant under the Congressionally-Identified Projects program (CFDA 11.617) to the University of Maryland, Baltimore (UMB) for the period of October 1, 2024 to September 30, 2026. The purpose of this grant is to accelerate structure-based drug and vaccine design programs that benefit human health by implementing state-of-the-art electron detection hardware to determine 3D structures of various biological compounds...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
Hummingbird Precision Machine Co. was awarded $313,383 on July 8, 2026, under the National Institute of General Medical Sciences' Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated mixing, inkjet deposition, and gas-assisted rapid freezing system for time-resolved cryogenic electron microscopy (cryo-EM) sample preparation. The project, led by Principal Investigator Norman Salmon, delivers a novel sample preparation platform that combines microfluidic mixing with precision inkjet dispensing and rapid cold-gas-assisted vitrification to enable millisecond-timescale temporal control of biomolecular sample capture—a critical capability absent in conventional cryo-EM sample preparation methods that require several seconds from sample application to freezing. The integrated system features an inkjet printhead with an embedded micromixer for on-demand sample mixing, programmable picoliter droplet deposition with defined spatial and temporal precision, and cold-gas vitrification to eliminate variability inherent in liquid cryogen-based freezing methods. By enabling the preparation of cryo-EM grids at precisely defined reaction time points, this platform will facilitate structural characterization of short-lived biomolecular intermediates and dynamic molecular transitions essential for disease mechanism elucidation and therapeutic advancement. The project is scheduled for completion on March 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $313.4k | 7/8/26 |