Project Grant R43GM163490
- The U.S. National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded a $432,834 Project Grant to the Board of Regents of the University of Nebraska on April 15, 2025. The grant supports the development of an "enzyme-free, label-free quantitative microarray technology" to detect and quantify target nucleic acids, such as microRNA, with high sensitivity down to the attomolar (10^-18 M) range....
- This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using...
- The National Institute of General Medical Sciences (NIGMS) awarded Fluorofinder, LLC a $356,190 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to advance a novel microscopy workflow tool. The tool is designed to streamline assay development, improve awareness and education around optimal selection of microscopy assay components (instruments and reagents), and enhance reproducibility in the field. The project aims to address common challenges in...
- This federal Project Grant award of $349,280 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of advanced machine learning algorithms for ultra-high-density, ultra-high-precision single molecule localization microscopy (SMLM). The grant recipient, Xgenomes Corp., will create a SMLM video simulator to generate training data (Aim 1), build a machine learning-based grouping...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $330,076 to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The award supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This innovative instrument is designed to enable non-destructive profiling and mapping of...
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,890,339 Project Grant under CFDA 93.859, Biomedical Research and Research Training, to the University of California Irvine (UCI) to develop novel "molecular lanterns" for multiplexed imaging of RNA dynamics. The key objectives are to: 1) Generate orthogonal RNA tags and complementary split luciferase binders to enable simultaneous visualization of multiple transcripts; and 2) Establish a platform for continuous,...
- This federal Project Grant award of $436,001 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to create a novel spatial transcriptomics platform that increases accessibility and efficiency. The key products and services to be delivered include: Developing a spatial transcriptomics platform using a simple filter array format that increases sequencing depth per spatial barcode, enabling more data per...
- This $1,416,590 federal Project Grant was awarded on August 6, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant recipient is Panluminate Inc., a woman-owned small business in New Haven, Connecticut specializing in advanced microscopy and spatial biology technologies. The key products and services to be delivered through this funding are: Developing a commercial prototype of an automated...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,316,016 Project Grant under CFDA Program 93.859 (Biomedical Research and Research Training) to the University of California, Irvine (UCI) to develop a novel biosensing platform for label-free, single-molecule detection at ultra-high speeds using metasurface-enhanced coherent Raman scattering. The 4-year project, running from September 2025 to August 2029, aims to overcome fundamental speed limitations in surface-enhanced...
This $306,788 federal Project Grant was awarded on September 30, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports the development of advanced probe technologies for ultrasensitive, quantitative RNA imaging using Hybridization Chain Reaction (HCR) amplification methods. The research aims to enable multiplexed, high-resolution imaging of gene expression patterns in highly autofluorescent biological samples such as whole-mount vertebrate embryos, thick brain slices, and formalin-fixed paraffin-embedded (FFPE) tissue sections. Key deliverables include: 1) straightforward multiplexing with 1-step quantitative signal amplification for up to 10 target mRNAs; 2) analog mRNA relative quantitation with subcellular resolution; 3) digital mRNA absolute quantitation with single-molecule resolution; and 4) automatic background suppression throughout the imaging protocol. The grant recipient is Molecular Instruments, Inc., a for-profit company in Los Angeles specializing in advanced scientific instruments and probes for biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.8k | 9/18/25 |