Project Grant R43GM161150
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...
- This $306,782 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the continued development and validation of a panel of six sialoglycan-recognizing probes (SGRPs) by Z Biotech, LLC. The project aims to optimize these specialized molecular tools, which leverage naturally evolved microbial sialoglycan-binding proteins, for use in common laboratory techniques like ELISA, Western...
- This federal Project Grant award of $183,494 from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), is for the development of a high-throughput multiplexed platform called "GLYCO-MAP" for profiling antibodies against glycosylated mucin proteins. The platform will leverage glycoengineered cell lines expressing homogeneous glycostructures to screen for tumor-associated autoantibodies, which can serve as cancer biomarkers for...
- The National Institute of General Medical Sciences (NIGMS) awarded a $382,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Texas A&M Engineering Experiment Station (Tees) for the project "Role of Membrane Dynamics in Cell Surface Glycan Recognition" from January 1, 2025 to December 31, 2029. The goal of this project is to investigate how the spatial organization of glycan ligands on cell membranes influences glycobiology processes, and to develop...
- This Project Grant award, valued at $417,243 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the synthesis of homogeneous proteoglycan-like glycopeptide and glycoprotein libraries for microarray studies. The goal is to develop innovative chemical, chemoenzymatic, and chemoselective ligation strategies to produce well-defined proteoglycan structures, which will then be incorporated into...
- This federal Project Grant award of $645,712 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of chemical biology tools to provide critical insights into protein post-translational modification (PTM) networks, with a focus on glycation and ubiquitination, in living cells. The research aims to unlock previously unattainable information to address questions about the role of these...
- This $327,085 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of new tools and strategies to advance the understanding of lectin proteins and their roles in human health. The key objectives of this 1-year project include: 1) Creating tools to assess how soluble human lectins interact with and influence microbial communities, 2) Developing a...
- The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $314,363 to Tango Biosciences Inc. to develop the AVIDIMER Platform - a molecular toolbox to accelerate proximity research and drug discovery. The key products and services to be delivered include: Development of a novel phage display-based AVIDIMER Platform to generate sustainable, recombinant affinity reagents with...
- The University of Southern California received a $342,342 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for their project titled "CHEMISTRY-ENABLED GLYCOSCIENCE." The project aims to develop and apply chemistry-enabled approaches to address unresolved questions in the field of glycoscience, which studies the role of glycans (complex carbohydrates) in biological processes and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $313,963 to Z Biotech, LLC to develop a comprehensive library and array of tumor-associated carbohydrate antigens (TACA). The goal is to create tools to systematically evaluate TACA interactions with therapeutic antibodies, biologics, and glycan-binding proteins, in order to advance the development of TACA-targeted diagnostics and treatments. The project will leverage Z Biotech's expertise in glycan synthesis and array fabrication to initially develop and validate a TACA library of 58 existing and 22 newly synthesized glycans/glycopeptides, particularly for MUC16 (CA125), STRA, and SLEA. This innovative TACA glycan array will simulate the diverse glycan presentations found on cancer cells, supporting broader research applications. The award period is from September 1, 2025 to August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $314.0k | 8/4/25 |