The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $2,297,901.00 to GMJ Technologies, Inc., a minority-owned small disadvantaged business, to develop a high-resolution native capillary zone electrophoresis system with inline UV and native mass spectrometry capabilities. This innovative analytical technology aims to improve the characterization and quality control...
The National Institute of General Medical Sciences (NIGMS) awarded a $338,843 project grant under CFDA 93.859 (Biomedical Research and Research Training program) to Nanoengineering Corporation (NEC) to develop an electrospray differential mobility analysis (ES-DMA) soft landing system. The goal is to overcome limitations of existing mass spectrometry-based protein separation and deposition techniques for cryogenic electron microscopy (cryo-EM) structural analysis. The project aims to demonstrate...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859, the Biomedical Research and Research Training program, provides $350,000 in funding to Electronic Biosciences, Inc. to develop a novel technology for high-accuracy, simultaneous sequencing of the RNA modifications pseudouridine (Ps) and N6-methyladenosine (M6A). The project aims to merge innovative bisulfite adduct sequencing methodology with Electronic Biosciences' enzyme-free, multi-pass...
The National Institute of General Medical Sciences (NIGMS) awarded a $358,862 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to GMJ Technologies, Inc., a minority-owned small business, to develop a microfluidic SDS depletion electrophoresis (SDE) interface. This interface will enable direct coupling of capillary electrophoresis with sodium dodecyl sulfate (CE-SDS) to mass spectrometry for improved characterization and quality control of monoclonal...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 Biomedical Research and Research Training provides $350,000 to Fluidispec LLC to develop a new microfluidic/nanofluidic sample preparation platform. The goal is to improve single-cell and low-input proteomics analysis by enabling efficient extraction of proteins from cells, removal of contaminants, and improved protein denaturation. This platform is expected to enhance...
The National Institute of General Medical Sciences (NIGMS) awarded a $905,853 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Molecular Instruments, Inc. to develop innovative signal amplification technologies for automated, ultrasensitive, and multiplex imaging of RNA and proteins in biological samples. The 2-year project aims to engineer novel chromogenic and fluorescent signal amplification cascades based on hybridization chain reaction (HCR) to enable 4-plex RNA in...
The National Institute of General Medical Sciences (NIGMS) awarded a $917,454 Project Grant under CFDA 93.859, Biomedical Research and Research Training, to Integral Molecular Inc. The grant supports the development of a novel Membrane Proteome Array (MPA) technology for specificity screening and profiling of biotherapeutics like monoclonal antibodies and CAR-T cell therapies. The MPA represents 93% of the human extracellular proteome expressed in native conformation, providing a more...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,566 to Biosensing Instrument Inc. to develop a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The SFNOA technology integrates several innovative techniques, including virion-displayed transmembrane...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,000 to Electronic Biosciences, Inc. to develop and demonstrate a novel enzyme-based, single-molecule protein sequencing system. The innovative platform aims to leverage enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high accuracy and throughput in protein analysis. Key objectives include demonstrating the system's ability to accurately sequence peptides with various post-translational modifications, surpassing current state-of-the-art methods. This technology has the potential to revolutionize protein analysis, facilitating rapid biomarker discovery and enhancing disease testing and monitoring, ultimately advancing biomedical research and public health.