Project Grant R43GM159438

Award Date 7/2/25
Completion Date 7/1/26
Dollars Obligated $348K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Colorado, USA
Similar Awards
This $306,872 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a commercial prototype for Fluid Discovery, Inc.'s "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." This transformative screening platform combines scalable hardware, label-free mass spectrometry, and advanced computational techniques to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, provides $757,299 to Abbratech Inc. to develop a comprehensive platform for identifying and validating recombinant antibodies specific to protein isoform splice-junction sites. The key products and services to be delivered under this "Directed Discovery and Validation of Anti-Splice-Junction Site Antibodies" project include: 1)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $303,024 to Biocognon LLC to develop an innovative combinatorial pipeline for discovering nanobody-based therapeutics targeting G-protein coupled receptors (GPCRs). The key products and services to be delivered under this award include: (1) developing a robust assembly system for GPCR and nanobody libraries, (2) building a...
This Project Grant award of $1,000,000 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports the development of Partillion Bioscience Corp's advanced antibody discovery workflows. The funding aims to enhance their specialized hydrogel microparticle technology called "nanovials" to enable ultra high-throughput screening and functional assessment of single B cells and antibody-secreting cells. This is expected...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology by Biosensing Instrument Inc. The SFNOA system aims to enable high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The $349,566 award, effective from April 2, 2025 to March 31, 2026,...
This federal Project Grant award in the amount of $271,495.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and evaluation of a time-of-flight (TOF) mass spectrometer system with matrix-assisted laser desorption/ionization (MALDI) for fast analysis of antibodies and related macromolecular immune complexes. The goal is to utilize a novel high-temperature superconducting...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $986,651 to Auragent Bioscience LLC (doing business as Brightest Bio) to develop an ultrabright fluorescent reagent called a Plasmonic Fluor (PF). The PF technology is designed to significantly enhance the detection sensitivity of fluorescent Western blot assays, enabling more precise protein concentration measurements and...
The National Institute of General Medical Sciences (NIGMS) awarded a $917,454 Project Grant under CFDA 93.859, Biomedical Research and Research Training, to Integral Molecular Inc. The grant supports the development of a novel Membrane Proteome Array (MPA) technology for specificity screening and profiling of biotherapeutics like monoclonal antibodies and CAR-T cell therapies. The MPA represents 93% of the human extracellular proteome expressed in native conformation, providing a more...
This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development and demonstration of a novel, enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. The innovative platform aims to leverage enzymatic processing and advanced bioinformatics to enable scalable, multiplexed protein sequencing with high accuracy and throughput. During this Phase I...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $348,492 to Fluorofinder, LLC to develop a novel digital workflow tool to simplify the identification of matched antibody pairs for improved immunoassay development. The key objectives of this 1-year project include expanding databases to facilitate comprehensive searching and comparison of proteins, developing a search/scoring algorithm and user interface, and conducting a feasibility study with end users to demonstrate proof-of-concept for the tool. The successful implementation of this Matched Pair Tool has the potential to significantly impact the field of immunoassay development by providing a streamlined, efficient method to reduce the number of antibody pairs that need to be empirically screened, thereby lowering costs and time associated with assay development while improving performance and reliability.

Generated 8/5/25, 5:53 AM