Project Grant R43GM157889
- This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop novel high-throughput machine learning approaches to study cell population-wide differences in subcellular object morphology, conformations, and organization using cryo-electron tomography (cryo-ET) data. The $371,427 award, granted on June 10, 2025, will support Carnegie Mellon University in addressing...
- This Project Grant award, valued at $1,963,850.00 and awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a novel "Differentiable Microscopy" technology at the Massachusetts Institute of Technology (MIT). The project aims to create a high-throughput, end-to-end imaging cytometry system by leveraging customizable nano-optics and machine learning techniques. The goal...
- The National Institute of General Medical Sciences (NIGMS) awarded Fluorofinder, LLC a $356,190 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to advance a novel microscopy workflow tool. The tool is designed to streamline assay development, improve awareness and education around optimal selection of microscopy assay components (instruments and reagents), and enhance reproducibility in the field. The project aims to address common challenges in...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
- This $306,788 federal Project Grant was awarded on September 30, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports the development of advanced probe technologies for ultrasensitive, quantitative RNA imaging using Hybridization Chain Reaction (HCR) amplification methods. The research aims to enable multiplexed, high-resolution imaging of gene expression patterns in highly autofluorescent...
- The National Institute of General Medical Sciences (NIGMS) awarded a $249,575 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University Enterprises, Inc. (UEI) at California State University, Sacramento. The award will fund the acquisition of a new Zeiss LSM 900 confocal laser scanning microscope to advance the research of three principal investigators studying the cellular and molecular aspects of neurodevelopmental and neurodegenerative diseases....
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
- This federal Project Grant award of $2,257,345.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new microscope capabilities to enable novel studies of biological processes at the University of North Carolina at Chapel Hill. Specifically, the research will combine new optical principles and computer vision to build autonomous microscopes that can rapidly capture and process...
- This $1,926,960 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Trustees of Boston University on September 15, 2025. The grant aims to develop new algorithms, engineer speckle illumination, and integrate these technologies into microscopes that enable high-speed, multicolor, and volumetric (multiplane) superresolution imaging using standard fluorescent molecules. The goal is to...
This federal Project Grant award of $349,280 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of advanced machine learning algorithms for ultra-high-density, ultra-high-precision single molecule localization microscopy (SMLM). The grant recipient, Xgenomes Corp., will create a SMLM video simulator to generate training data (Aim 1), build a machine learning-based grouping algorithm to improve the speed and accuracy of existing SMLM data analysis (Aim 2), and develop a machine learning model to analyze whole SMLM videos at once to achieve significantly higher emitter density detection compared to current methods (Aim 3). The successful completion of these aims will provide the academic research community with advanced SMLM analysis tools to enable higher-resolution molecular imaging and address critical challenges in areas such as cancer research and diagnostics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $349.3k | 9/9/25 |