Removal of palladium from pharmaceutical process chemistry reactions
Ended Project Grant Awarded Last action
- Award ID
- R43GM157773
- Recipient
-
Palladias LLC UEI N1VRMZTBH195
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $280,160
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date
- Place of performance
- Los Alamos, NM 87544, USA
Award details come from USAspending.gov.
Description
- Abstract
- (30 lines) palladias will develop inexpensive and reusable sorbents that cost effectively remove palladium from the products of palladium-catalyzed cross-coupling reactions. Palladium-catalyzed cross-coupling reactions are among the most widely used reactions in pharmaceutical discovery. Nigms has invested approximately $107 million in researching and developing palladium-catalyzed cross-coupling reactions. This project addresses the nigms topic: "synthetic chemistry to efficiently produce methods for molecules of biomedical significance." despite their versatility and power, these reactions are not widely used in pharmaceutical process chemistry to synthesize medicines on a production scale because of the difficulty of removing the palladium catalysts from the products of these reactions. Palladias proposes to use high throughput screening to generate chelating sorbents to remove residual palladium from a set of three common palladium-catalyzed reactions. Palladias has developed high-throughput screening technology to identify highly selective sorbents that selectively extract metals from complex matrices. This screening technology identifies selective sorbents from combinatorial libraries. Palladias will screen for palladium scavengers, and characterize the sorbents identified in this project for reusability, kinetics, and binding affinity.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $280,160 |
Quick answers
Who received award R43GM157773?
R43GM157773 was awarded to Palladias LLC by National Institute of General Medical Sciences (National Institutes of Health) on May 1, 2025.
How much is award R43GM157773 worth?
$280,160 has been obligated on R43GM157773.
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