This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting the development of an optimized, off-the-shelf alternative to autologous fat grafting for soft tissue repair. The $293,983 award to Insoma Bio, Inc., a biotechnology company in Durham, North Carolina, will evaluate the combination of Insoma Bio's Fractomer tissue repair matrix and the Renuva adipose allograft material from MTF...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a hyperstable and bioactive FGF1-FGF2 dimer formulation for effective healing of diabetic skin wounds. The $435,226 award to the University of Arkansas will fund research activities across three key objectives: Designing a hyperstable and bioactive FGF1-FGF2 dimer and its variants, Developing injectable anionic...
This Project Grant award of $305,000 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of an advanced wound care product for treating diabetic foot ulcers. The product is a microneedle bandage that delivers three therapeutic agents to disinfect the wound, prevent bacterial biofilm re-formation, and activate the immune system to facilitate healing. Initial work will be conducted using skin tissue cultures and testing...
This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), aims to develop a novel therapeutic approach to improve angiogenesis and wound healing by delivering apoptotic neutrophils within a degradable hydrogel scaffold. The $172,700 award, effective August 20, 2024 through July 31, 2026, supports research to investigate the effects of the hydrogel-apoptotic neutrophil delivery on macrophage angiogenic signaling and its impact...
The National Institute of General Medical Sciences (NIGMS) awarded a $801,650 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois for the project "Spatio-Temporal Cellular Dynamics Regulating Differential Healing Outcomes". The goal is to use state-of-the-art single cell and spatial sequencing technologies combined with a new analytical framework to systematically compare cell type dynamics, cell-cell interactions, and...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $305,000 to LF Printech LLC, a minority-owned small business, to develop a novel bioactive hydrogel dressing with a porous surface for the treatment of second-degree burn wounds. The dressing is designed to accelerate natural healing, reduce pain and trauma associated with dressing changes, and address critical gaps in existing burn wound...
The National Institute of General Medical Sciences (NIGMS) awarded a $400,000 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to Baylor College of Medicine to develop and optimize bioengineered polymers that can modulate inflammatory responses and enhance tissue repair and regeneration in wound healing. The 5-year project aims to systematically investigate how the chemical and mechanical properties of biopolymers, such as surface charges, elasticity, and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to advance the understanding of how nanogenerator-driven electrical stimulation can accelerate wound healing. The $469,766 project will investigate the cellular-level mechanisms underlying this approach and identify optimal signal and device designs to deliver the desired therapeutic effect....
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports the development of a novel peptide-based therapeutic agent called M10 for the treatment of skin fibrosis associated with systemic sclerosis (scleroderma). The $613,036 award to Fibrobiologics LLC aims to determine the antifibrotic activity of M10 in primary skin fibroblasts from scleroderma...
This $367,577 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to Adepthera LLC aims to develop a regenerative peptide therapy to accelerate pressure ulcer healing. Specifically, the award will fund research to identify an optimal formulation of a self-assembling adrenomedullin (ADM) analog gel that can improve local blood circulation and wound healing in aging and diabetic mouse models. The proposed therapy would be administered weekly or biweekly via...