The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Sindri Materials Corp, a for-profit veteran-owned manufacturer, to investigate the development of an optimized graphene-based architecture for cryogenic electron microscopy (cryo-EM) to address challenges in macromolecule imaging. The goal is to create a reliable, reproducible, and rapid cryo-EM integration solution using...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $338,843 to Nanoengineering Corporation to design, build, and test an Electrospray Differential Mobility Analysis (ES-DMA) soft landing system. The goal is to improve structural preservation and resolution of cryo-EM data for clinically relevant protein targets, such as higher-order oligomeric states of DNAJB6 linked to Alzheimer's...
The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $792,584 to Old Dominion University and its affiliated research foundation to develop multi-resolution docking methods and computational modeling tools for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET). The 5-year project aims to advance flexible fitting and refinement of AlphaFold2 models, improve...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $276,000.00 to the Scripps Research Institute in La Jolla, CA to develop graphene grids to overcome air-water-interface issues in single particle cryo-electron microscopy (cryo-EM). The grant aims to overhaul the cryo-EM grid preparation process to abolish air-water interface interactions, which can damage fragile biological...
This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development and demonstration of a novel, enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. The innovative platform aims to leverage enzymatic processing and advanced bioinformatics to enable scalable, multiplexed protein sequencing with high accuracy and throughput. During this Phase I...
The National Institute of Standards and Technology (NIST) awarded a $963,000 Project Grant under the Congressionally-Identified Projects program (CFDA 11.617) to the University of Maryland, Baltimore (UMB) for the period of October 1, 2024 to September 30, 2026. The purpose of this grant is to accelerate structure-based drug and vaccine design programs that benefit human health by implementing state-of-the-art electron detection hardware to determine 3D structures of various biological compounds...
The National Institute of General Medical Sciences (NIGMS) awarded a $395,455 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Purdue University. The grant, effective August 1, 2025 through July 31, 2030, will support the development and application of computational methods for biomolecular structural modeling of cryo-electron microscopy (cryo-EM) data. Key objectives include enhancing structure modeling capabilities to improve accuracy and efficiency,...
This $1,999,999 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will establish a Midwest Regional Cryo-Electron Microscopy (Cryo-EM) Facility at the University of Kansas Medical Center (KUMC). The award will fund the acquisition of a Glacios 200 kV Cryo-TEM equipped with a Falcon 4i detector and Selectris energy filter to provide high-resolution structural analysis capabilities for researchers...