This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...
This $308,925 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of novel computational methods and software tools by Chemia Biosciences, Inc. to discover new fungal natural products with potential antimicrobial, antitumor, and antifungal applications.
The primary objectives are to leverage high-throughput mass spectrometry and genome mining techniques to create...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $387,579 to Oregon Health & Science University (OHSU) to advance computational modeling of disease metabolism by integrating artificial intelligence and systems biology. The key objectives are to: 1) systematically characterize metabolic landscapes in disease systems, 2) leverage multi-omics data and knowledge...
Omicscraft LLC received a $256,000 Project Grant from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041) to develop a cloud-based platform for analysis of untargeted metabolomics data. The platform will provide users an interactive modular interface to build customized pipelines for metabolomics data analysis from February 15, 2022 through July 31, 2022. Key deliverables include innovative computational methods for...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded Talus Bioscience Inc. a $398,441 Project Grant (R43GM146472) to develop machine learning algorithms that can accelerate drug discovery by increasing the throughput of proteomics experiments and simplifying the analysis of compound-protein interactions. Specifically, the project aims to create a "compressed sensing" algorithm to reconstruct...
This $350,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of an artificial intelligence (AI)-based platform for peptide lead optimization. The platform will enable researchers to model the potency, solubility, stability, and permeability of peptides, including those containing non-canonical amino acids and cyclic structures. The goal is to expedite peptide...
The National Institute of General Medical Sciences (NIGMS) awarded Biocognon LLC a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) in the amount of $303,024 to develop an innovative combinatorial pipeline for discovering anti-GPCR nanobodies. The project aims to overcome limitations in current antibody discovery platforms by leveraging Biocognon's yeast dual biosensor technology to enable screening of multiple GPCR targets simultaneously without...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,739,977 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Eclipse Bioinnovations, Inc. to develop the EMOA (Enhanced Multi-Omic Analysis) platform. This platform will use a combination of transcriptomics and translatomics to rapidly identify the mechanism of action for drug candidates during the drug discovery process. The goal is to shorten the research cycle for biotech and pharmaceutical...
This $752,456 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development and application of innovative computational technologies for computer-aided drug discovery (CADD) at the University of Pittsburgh.
The key objectives are to: 1) Create a large database of predicted protein-ligand complexes to improve the accuracy of structure-based machine learning models for assessing small...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluidispec LLC in Philadelphia, PA. The funding supports the development of a microfluidic/nanofluidic sample preparation platform to enable enhanced low-input and single-cell proteomics analysis. The project aims to improve protein extraction, purification, and denaturation to overcome longstanding challenges in top-down and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,000 in funding to Sinopia Biosciences Inc. to develop computational methods and data standards for large-scale metabolomics analysis in the context of data-driven drug discovery.
The key products and services to be delivered under this 1-year award include developing standardized computational pipelines for generating and comparing metabolomics profiles, and testing these methods using computational benchmarking and experimental validation. This work aims to address key technical challenges that have precluded the systematic use of metabolomics data for phenotypic drug discovery approaches. The project will also expand Sinopia's metabolomics-based drug discovery platform by increasing the chemical library coverage and integrating metabolomics data with gene expression analysis. The platform is intended to be commercialized through Sinopia's own drug development efforts and/or partnerships with biotech and pharmaceutical companies.