Project Grant R43GM154542
Award Date
9/20/24
Completion Date
9/19/25
Dollars Obligated
$271K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Madison, WI 53717, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $283,805 to Invizyne Technologies, Inc. to develop a high-throughput platform for engineering enzymes capable of performing "bioclick" group transfer reactions. The platform integrates cell-free protein synthesis with multiplexed mass spectrometry to rapidly screen enzyme variant libraries against diverse substrates. Key...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $299,978 to Lifesensors Inc., a biotechnology company specializing in ubiquitin and ubiquitin-like protein research tools and services. The award supports the development of novel technology platforms to enable the rational design of molecular glue degraders, a class of protein degradation modulators, with a focus on the LRRK2 protein...
This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development and demonstration of a novel, enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. The innovative platform aims to leverage enzymatic processing and advanced bioinformatics to enable scalable, multiplexed protein sequencing with high accuracy and throughput. During this Phase I...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology by Biosensing Instrument Inc. The SFNOA system aims to enable high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The $349,566 award, effective from April 2, 2025 to March 31, 2026,...
This $306,872 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a commercial prototype for Fluid Discovery, Inc.'s "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." This transformative screening platform combines scalable hardware, label-free mass spectrometry, and advanced computational techniques to...
The National Institute of General Medical Sciences (NIGMS) awarded a $314,363 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Tango Biosciences Inc. in Chicago, Illinois. The grant supports the development of the Avidimer Platform, a novel phage display-based technology to create affinity reagents and enable high-throughput screening for identifying "molecular glues" - small molecules or biologics that induce proximity between two protein...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $303,024 to Biocognon LLC to develop an innovative combinatorial pipeline for discovering nanobody-based therapeutics targeting G-protein coupled receptors (GPCRs). The key products and services to be delivered under this award include: (1) developing a robust assembly system for GPCR and nanobody libraries, (2) building a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $350,000 to Sinopia Biosciences Inc. to develop computational methods for predicting the metabolomic profiles of unscreened chemical compounds. The goal is to enable more efficient metabolomics-based drug discovery by combining sparse experimental screening with computational inference. Key objectives include: 1) developing methods to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a novel computational platform for discovering non-ribosomal peptide natural products. The $781,502 award to Chemia Biosciences, Inc., a small disadvantaged business in Pittsburgh, PA, aims to create efficient and accurate methods for identifying new natural product small molecules from complex mass...