The National Institute of General Medical Sciences (NIGMS) awarded a $700,000 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to Mirimus, Inc., a self-certified small disadvantaged business located in Brooklyn, NY. The grant funding, with a period of performance from September 20, 2024 to April 19, 2025, will support the creation of next-generation RNA interference (RNAi) therapeutics and the development of an in vivo mouse model to evaluate their efficacy and biodistribution. Specifically, the project aims to generate a pipeline for testing a variety of RNAi-based therapeutic biologics, including those coupled to peptide, aptamer, and viral vector delivery platforms. The researchers will utilize a novel transgenic mouse model containing fluorescent reporters to systematically assess the tissue penetration, cellular uptake, and potential off-target effects of these RNAi-based drug candidates in a live animal setting. This research is expected to accelerate the development and evaluation of innovative oligonucleotide-based therapeutics for complex medical conditions.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 12/11/24 | ||
| Not listed | $350.0k | 9/20/24 | ||
| Not listed | $350.0k | 9/20/24 |