This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the field of native mass spectrometry (MS) analysis. The $316,825 award, effective May 1, 2025 through April 30, 2026, supports the development of an innovative intact mass deconvolution method designed to improve the speed, accuracy, and user-friendliness of proteins and nucleic acid molecular weight...
This federal Project Grant award for $417,400.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and advancement of mass spectrometry imaging (MSI) tools to enable more accurate and comprehensive chemical characterization of the glycome at tissue and cellular resolutions. The research aims to overcome current limitations in glycome imaging by utilizing various ionization...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $338,843 to Nanoengineering Corporation to design, build, and test an Electrospray Differential Mobility Analysis (ES-DMA) soft landing system. The goal is to improve structural preservation and resolution of cryo-EM data for clinically relevant protein targets, such as higher-order oligomeric states of DNAJB6 linked to Alzheimer's...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $304,196 to Laser Bioanalytics LLC for the development of a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable improved mass spectrometry structural analysis and imaging of lipids, which are important cellular components relevant to disease diagnosis...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), aims to improve the sensitivity and selectivity of laser desorption ionization for mass spectrometry through the use of N-heterocyclic carbene (NHC) mass ionization tags. The $442,466 award, effective September 1, 2024 through August 31, 2026, will fund proof-of-concept experiments to demonstrate that NHC-decorated gold...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology by Biosensing Instrument Inc. The SFNOA system aims to enable high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The $349,566 award, effective from April 2, 2025 to March 31, 2026,...
This $306,872 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a commercial prototype for Fluid Discovery, Inc.'s "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." This transformative screening platform combines scalable hardware, label-free mass spectrometry, and advanced computational techniques to...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), awarded a $1,469,739 Project Grant to the Research Foundation of the City University of New York (RFCUNY) to purchase a TIMSTOF-FLEX MALDI-2 high-resolution mass spectrometer. This advanced instrumentation will support biomedical research projects across 12 laboratories from CUNY and nearby institutions, focusing on areas such as conformational dynamics of...
The National Institute of General Medical Sciences (NIGMS) awarded a $265,939 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to Trustees of Indiana University, doing business as Indiana University, to advance high-resolution charge detection-mass spectrometry (CD-MS) technology. The project aims to address the two main limitations of CD-MS: its moderate resolving power and the relatively long time needed to measure a spectrum. Key objectives include...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), is funding research at Brigham Young University (BYU) to develop advanced mass spectrometry-based technologies for profiling biomolecular expression at the single-cell level. The $1,317,836 award, with a project period from September 1, 2024 to July 31, 2029, will support the development of global and targeted...