The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Molecular Instruments, Inc., a for-profit manufacturer of scientific instruments, in the amount of $905,853. The funding will support the company's research and development of advanced technologies for automated, ultrasensitive, and multiplex imaging of RNA and proteins in biological samples. Specifically, the project aims to engineer...
This $349,816 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to develop a prototype instrument, software, and consumable for non-invasive identification, tagging, and downstream characterization of live cells. The product will enable researchers to study clinically relevant cell-cell interactions, which drive many challenging diseases like cancer, autoimmunity, and neurological disorders....
The National Institute of General Medical Sciences (NIGMS) awarded a $283,805 Project Grant under CFDA 93.859 (Biomedical Research and Research Training) to Invizyne Technologies, Inc., a small disadvantaged business based in Monrovia, California. The project, titled "BIO-CLICK: A CELL-FREE HIGH-THROUGHPUT PLATFORM FOR THE ENGINEERING OF ENZYMATIC GROUP TRANSFER REACTIONS", focuses on developing a novel cell-free, high-throughput platform to expedite the engineering of enzymes for...
This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems Project Grant of $500,000 awarded to Beth Israel Deaconess Medical Center, Inc. (Bidmc) aims to develop a novel, label-free method for dynamically sensing chromatin packing and structure in live cells. The 3-year project leverages the principles of fractal sensing and coherent confocal light absorption and scattering spectroscopic microscopy to create a 3D dynamic map of chromatin...
This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) Project Grant award of $613,746 to Osem Fluidics Inc. aims to develop 3D-printed microfluidic channel architectures to precisely control the structure and properties of lipid nanoparticles (LNPs) for enhanced nucleic acid delivery. The research focuses on designing, simulating, and testing various 3D channel configurations to manipulate flow conditions and tailor LNP...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Cellecho, Inc. aims to develop a microchip-based technology for advanced cell engineering. The key products and services to be delivered under this award include: The proposed microchip technology will leverage sound waves and electric fields to precisely manipulate cells and sequentially deliver customizable combinations of genetic materials such as DNA, mRNA, and...
The federal Project Grant award of $5,037,617 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports Chromatan Inc.'s development and scale-up of its Continuous Countercurrent Tangential Chromatography (CCTC) platform for the purification of recombinant adeno-associated virus (rAAV) vectors used in gene therapies. The key objectives of this project are to: 1) develop a comprehensive process development toolkit...
The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York, NY. The grant, titled "Proximity Copy Paste: A Methodology for Single-Molecule Analysis of Chromosome Structure," will support the development of novel approaches to map the folding and protein occupancy of entire chromosomes with single-nucleosome resolution and...
The National Institute of General Medical Sciences (NIGMS) awarded a $364,969 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to North Carolina State University (NC State) effective September 15, 2024. The overarching goal of this 5-year project is to develop a toolbox of switchable and functional fluorescent probes to enable multi-functional super-resolution microscopy (MF-SRM) for studying complex molecular interactions and biophysical changes within...
This $752,456 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and application of innovative computational technologies for the design of small-molecule ligands. The key products and services to be delivered over the 5-year project period include: Creating a large database of predicted protein-ligand complexes to improve the accuracy of structure-based machine learning...