High-throughput discovery of antibodies against understudied membrane proteins
Ended Project Grant Awarded Last action
- Award ID
- R43GM150317
- Recipient
-
Integral Molecular Inc. UEI DY9KSWE8EJB8
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $295,924
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date
- Place of performance
- Philadelphia, PA 19104, USA
Award details come from USAspending.gov.
Description
- Abstract
- Of the 20,000 genes in the human genome, approximately 4,000 are considered "druggable" by pharmaceuticals. However, less than 10% of these druggable proteins are actually targeted by FDA-approved drugs. In 2014, the illuminating the druggable genome (IDG) project was launched by the NIH in recognition that there is a potentially large number of druggable targets with high therapeutic value that are undiscovered or understudied. The IDG selected 230 g protein-coupled receptors (gpcrs) and ION channels as a focus of their program, as these families make up the largest families of the druggable genome and have high potential to impact human health. Due to their difficult biology, many of them are completely unexplored. To enable this research, the IDG has called for the development of reagents such as monoclonal antibodies (mabs) against these 230 gpcrs and ION channels, only 10% of which currently have commercially available mabs. A novel approach to identify membrane protein mabs in a high-throughput manner is needed to derive mabs against the entire druggable human membrane proteome.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $295,924 |
Quick answers
Who received award R43GM150317?
R43GM150317 was awarded to Integral Molecular Inc. by National Institute of General Medical Sciences (National Institutes of Health) on May 1, 2023.
How much is award R43GM150317 worth?
$295,924 has been obligated on R43GM150317.
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