The National Institute of Standards and Technology (NIST) awarded a $400,000 Cooperative Agreement under the Science, Technology, Business and/or Education Outreach program (CFDA 11.620) to Sygnamap Inc., a minority-owned for-profit company located in San Antonio, Texas. The purpose of this 2-year project is to develop a computational quantitative normalization approach from calibration standards that will improve the application of matrix-assisted laser desorption/ionization mass spectrometry...
This $255,994 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) will fund Sygnamap Inc. to develop a computational platform using spatial omics data to infer putative causative pathways of kidney disease. The platform will leverage mass spectrometry imaging and artificial intelligence/machine learning approaches to correlate and optimize the localization of molecules with pathologic features. This will identify key biochemical pathways that drive disease...
This Project Grant award of $532,947 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund the development and validation of a unified, cloud-based data processing workflow and database called LC-BINBASE for high-resolution LC-MS/MS metabolomics and lipidomics data. The goal is to create a standardized and reproducible metabolomics data processing system that can be used across different laboratories and mass...
This $435,827 Project Grant from the National Cancer Institute (NCI) under the CFDA 93.394 Cancer Detection and Diagnosis Research program supports research conducted by New York University (NYU) School of Medicine to develop deep learning methods for analyzing mass spectrometry imaging (MSI) data. The goal is to make MSI data more accessible to existing machine learning workflows by expanding the dimensionality of the data structure to treat each metabolite or lipid as an individual "color...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides funding of $258,586 to MSTM LLC to develop an advanced surface sampling and ionization technology for remote detection of molecular compositions. The goal is to demonstrate the feasibility and proof-of-concept of a "Surface Reader" device that can directly sample surfaces using a liquid meniscus or indirectly via laser...
This $255,706 National Science Foundation SBIR Phase I Project Grant to Metfora LLC supports the development of a novel multiplexed metabolite diagnostic blood test for early detection of chronic diseases. The NSF Technology, Innovation, and Partnerships program aims to advance science and engineering solutions to national challenges through innovation and partnerships. Specifically, Metfora will use mass spectrometry and artificial intelligence to analyze specific panels of circulating...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $304,196 to Laser Bioanalytics LLC for the development of a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable improved mass spectrometry structural analysis and imaging of lipids, which are important cellular components relevant to disease diagnosis...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $316,825 in funding to Massmatrix Inc. to advance native mass spectrometry (MS) analysis. The key objectives are to: 1) implement enhanced deconvolution techniques to reduce artifacts and optimize processing speed without sacrificing accuracy; 2) automate spectrum reconstruction for efficient handling of diverse analytical...
The National Institute of General Medical Sciences (NIGMS) awarded a $417,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Battelle Memorial Institute's Pacific Northwest National Laboratory (PNNL) to develop and advance mass spectrometry imaging (MSI) tools for more accurate and comprehensive chemical characterization of the glycome at tissue and cellular resolutions. The award, with a period of performance from April 10, 2025 to March 31, 2030, aims to...