Project Grant R43GM146560

Award Date 9/20/24
Completion Date 9/19/25
Dollars Obligated $599K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Evanston, IL 60201, USA
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The National Institute of General Medical Sciences (NIGMS) awarded a $599,409 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Opera Bioscience, Inc., a woman-owned small business located in Evanston, Illinois. The grant supports the development of a novel bacterial protein secretion platform to produce cost-effective recombinant proteins and growth factors for therapeutic applications.

Specifically, Opera Bioscience proposes to adapt its existing platform, which utilizes the Type III Secretion System of Salmonella Enterica Typhimurium, to optimize a production strain and define an optimal growth environment to maximize secreted protein titers. The goal is to create a streamlined, scalable process for manufacturing high-purity recombinant proteins and growth factors that can reduce costs and support the production of therapeutics, including emerging cell-based therapies. The 12-month project period runs from Sep 20, 2024 to Sep 19, 2025.

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