Multi-omics profiling of individual exosomes for their origin-tracing, biomarker discovery, and biological function characterization

Ended Project Grant Awarded Last action

Award ID
R43GM145015
Recipient
Awarding agency
Obligated
$256,474

Award facts

Assistance listing
93.859 Biomedical Research and Research Training
Completion date
Originally
Place of performance
California, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Exosomes, the small extracellular vesicles (30-200 NM), are highly heterogeneous in biofluids. However, traditional bulk-level analysis approaches fail to represent their individual variations. A technique for multi-omics profiling of exosomes at single-particle resolution is of great interest to the exosome research field, but has yet to be developed. Wellsim proposes to develop and validate a method for multi-omics profiling of individual exosomes based on our exosome isolation system (EXODUS), a droplet-based microfluidic device (EXOSEQ), and next-generation sequencing (NGS). Our proposed technique will be the first integrative proteomic and transcriptomic profiling of exosomes at the single-particle level, offering high-resolution multi-dimensional biological insights for exosome study and application.

Transactions

Action Obligated Date
Amendment $0
Amendment $6,500
Original award $249,974

Quick answers

Who received award R43GM145015?

R43GM145015 was awarded to Wellsim Biomedical Technologies Inc. by National Institute of General Medical Sciences (National Institutes of Health) on February 10, 2022.

How much is award R43GM145015 worth?

$256,474 has been obligated on R43GM145015.

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