Sprayable hydrogel barrier for the delivery of adhesion-preventing therapeutics
Ended Project Grant Awarded Last action
- Award ID
- R43GM144991
- Recipient
-
Luna Labs USA LLC UEI M6JVSYRQRYM9
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $507,414
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date
- Place of performance
- Virginia, USA
Award details come from USAspending.gov.
Description
- Abstract
- Adhesion formation after intra-abdominal surgery poses a significant health risk, cited as a leading cause of small bowel obstruction and female infertility. Methods to prevent these adhesions are currently limited to barrier films, which are difficult to place and are often restricted to use preventing adhesions to the surgical incision site, leaving the bulk of the abdominal contents unprotected. These barrier products also fail to address the tissue response that causes most adhesions. This program will focus on the optimization of a low-cost, sprayable barrier that will flow around and adhere to the internal tissues of the abdominal cavity, providing protection from adhesions for all internal surfaces. This hydrogel will also deliver anti-inflammatory or fibrinolytic therapeutics to mitigate local biological responses responsible for adhesion formation. Luna labs will optimize the product formulation using in vitro characterization before completing preliminary validation of efficacy in a rodent abdominal model of adhesion formation. These results will support a phase II transition effort towards product commercialization and submission to the FDA.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | -$34,048 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $270,731 | |
| Original award | $270,731 |
Quick answers
Who received award R43GM144991?
R43GM144991 was awarded to Luna Labs USA LLC by National Institute of General Medical Sciences (National Institutes of Health) on September 20, 2023.
How much is award R43GM144991 worth?
$507,414 has been obligated on R43GM144991.
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