Cornell University received a $100,000 Project Grant award from the National Science Foundation's Technology, Innovation, and Partnerships program to develop a cell-free biosensing platform integrating transmembrane proteins. The award period is from July 1, 2022 to December 31, 2022. Specifically, the university will utilize recent advances in biotechnology and bioelectronics to establish a process for rapidly assembling customized transmembrane proteins into a biomimetic sensing device without...
This $383,799 National Science Foundation project grant supports collaborative research to map protein-membrane interactions across molecular to cellular scales. Funded under the Biological Sciences program (CFDA 47.074), the research aims to better understand how integral membrane proteins and surrounding phospholipid membranes work together to enable cellular processes. The University of Arizona will conduct multiscale modeling from molecular dynamics simulations of single protein-membrane...
This $350,000 Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under the 93.350 CFDA program, supports the development of the Codomax EPI-MAX platform. This integrated omics and computational technology leverages cellular stress responses to enhance the production of difficult-to-express therapeutic proteins, with a focus on improving secretion and preventing aggregation in the Pichia pastoris expression system. The key products or services to be...
This Project Grant award of $410,939 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Clemson University to elucidate the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, such as atomic force microscopy, to probe how membrane proteins interact with cell membranes, maintain proper orientation, and achieve their final folded state during...
The National Institute of General Medical Sciences (NIGMS) awarded a $917,454 Project Grant under CFDA 93.859, Biomedical Research and Research Training, to Integral Molecular Inc. The grant supports the development of a novel Membrane Proteome Array (MPA) technology for specificity screening and profiling of biotherapeutics like monoclonal antibodies and CAR-T cell therapies. The MPA represents 93% of the human extracellular proteome expressed in native conformation, providing a more...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...
This Project Grant award for $803,808 from the National Science Foundation's Biological Sciences (CFDA 47.074) program will support research at New York University (NYU) to investigate the evolution of membrane protein transporters. The research aims to determine how mutations in these proteins impact their dynamics, conformational states, and transport directionality, providing insights into membrane protein biogenesis. The project will involve training students and postdoctoral associates in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $283,805 to Invizyne Technologies, Inc. to develop a high-throughput platform for engineering enzymes capable of performing "bioclick" group transfer reactions. The platform integrates cell-free protein synthesis with multiplexed mass spectrometry to rapidly screen enzyme variant libraries against diverse substrates. Key...
This Project Grant award from the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Tectaria Bio LLC to engineer cell lines with activated proteasomes for increased biomanufacturing efficiency. The project aims to test the feasibility and application of a novel technology to significantly increase the protein production capabilities of cell lines used in the manufacture of biologics, gene therapies, and vaccines....
This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development and demonstration of a novel, enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. The innovative platform aims to leverage enzymatic processing and advanced bioinformatics to enable scalable, multiplexed protein sequencing with high accuracy and throughput. During this Phase I...