Project Grant R43GM135984

This Project Grant award of $408,007 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a technology called "glycosequencing" that uses next-generation sequencing (NGS) to sequence and quantify glycan structures. The project will first identify an optimal set of lectins, biochemically characterize them, and prepare lectin barcoding for NGS. It will also build a training dataset using recombinant proteins produced in glycoengineered Chinese...

This National Science Foundation (NSF) Partnerships for Innovation - Research Partnerships (PFI-RP) project grant, CFDA #47.084, provides $549,649 to the University of Rochester to advance the development of a novel membrane-based sensor technology for the rapid and specific detection of infectious pathogens in biofluids. The project aims to integrate the membrane sensor into a hand-operated microfluidic device with a colorimetric readout, and demonstrate the generalizability of the approach...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $306,710 to Z Biotech, LLC in Aurora, CO to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to improve upon existing glycan binding assays and optimize glycan structure analysis software to create a new low-cost platform for glycan isomeric structure analysis. Key objectives...

This $249,000 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of a novel split enzyme diagnostic platform for rapid, sensitive detection of protein and small molecule biomarkers at the point of care. The key objectives of this 3-year project are to: 1) incorporate binding domains into a split adenylate...

This National Science Foundation (NSF) Engineering (CFDA 47.041) grant, awarded to the Rector & Visitors of the University of Virginia, aims to develop innovative, biology-inspired materials for purifying protein-based therapeutics. The $600,000 project will span 5 years, starting on February 1, 2025. Key objectives include: Designing mixed-mode peptide ligands to selectively adsorb and purify protein therapeutics from contaminants like viruses, unwanted proteins, and misformed products. The...

The National Institutes of Health National Institute of General Medical Sciences awarded a $903,000 Project Grant to The University of Toledo to develop new glycosylation methods for microbial glycan synthesis under the Biomedical Research and Research Training program (CFDA 93.859). Over a three-year period from September 2022 to August 2025, the University will create two new catalytic glycosylation methodologies - a cationic gold(I)-catalyzed glycosylation using glycosyl...

This National Science Foundation (NSF) Engineering grant award, under the CFD Program 47.041, provides $150,000 to the University of Georgia Research Foundation to develop novel methods for high-throughput, antibody-free cell sorting. The project, titled "EAGER: IMPRESS-U: HIGH-THROUGHPUT AGILE INTERFACES FOR CELL SORTING," aims to create an alternative, scalable approach to efficiently separate therapeutic cells from unwanted or damaged cells for biomedical applications. The...

This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program aims to synthesize a comprehensive library of 38 unique sulfated O-GalNAc glycans using a Sulfated Modular Synthesis / Enzymatic Assembly (SMSEA) approach. The $290,986 award to Chembind LLC, a minority-owned small business, will enable the development of this invaluable toolkit for functional glycomics research. The project also innovates...

This $228,697 National Science Foundation award under the Engineering program (CFDA 47.041) will support the development of an optical biosensor technology to facilitate drug screening and validation efforts. Auctus Biologics, Inc. will utilize a proprietary temperature, pH, and chemically stable protein composed of two fragments that bind with antibody-like affinity and specificity. Over the one-year period ending January 2023, the company will establish the technology's suitability for...