Project Grant R43GM131444

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides funding of $306,710 from January 1, 2025 to December 31, 2025 to develop a new glycan binding protein (GBP)-based glycosylation analysis system. The key products and services to be delivered under this award include: Expanding the available data used for predicting glycan binding by collecting a large glycan array dataset with a...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund the design and preparation of diagnostic biomarker reference standards for mucopolysaccharidosis type I (MPS-I) and type II (MPS-II). These lysosomal storage disorders are included in newborn screening programs, but current first-tier enzyme activity screening has a high rate of false...

The National Institute of General Medical Sciences (NIGMS) awarded a $358,862 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to GMJ Technologies, Inc., a minority-owned small business, to develop a microfluidic SDS depletion electrophoresis (SDE) interface. This interface will enable direct coupling of capillary electrophoresis with sodium dodecyl sulfate (CE-SDS) to mass spectrometry for improved characterization and quality control of monoclonal...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...

This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $308,299 to the University of Texas at Austin (UT Austin) supports the development of novel methods to sequence, visualize, and analyze glycosylated RNAs (glycornas) across diverse organisms, including humans, plants, yeast, and bacteria. The key products and services to be delivered under this 3-year award include: Creating an unbiased enrichment method for glycornas using glycan-specific...

This $456,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of an automated microscale approach to customize enzyme-based remodeling of N-linked glycans. The goal is to provide a flexible, scalable tool for producing standardized glycoform products in small quantities to facilitate research on the complex role of glycosylation in human health. The project involves two...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel in-line biomanufacturing process analytical technology tool. The $302,417 award to Physical Sciences Inc. (PSI), in collaboration with the University of Massachusetts Lowell (UML), aims to enable real-time monitoring of biomolecules in large-scale bioreactors for gene therapy manufacturing. The technology...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to develop a bioinformatics workflow to profile glycan utilization in human gut microbiomes. The $294,431 award to the University of Nebraska will establish reference databases of carbohydrate-active enzymes and gene clusters to enable personalized analysis of fiber utilization across diverse human populations, including underrepresented...

This $786,132 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the continued development and expansion of computational tools and their applications in various biological systems. The key products and services to be delivered under this 5-year award include: Further development and enhancement of the CHARMM-GUI web-based platform to enable more advanced biomolecular modeling and...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,000 to Electronic Biosciences, Inc. to develop and demonstrate a novel enzyme-based, single-molecule protein sequencing system. The innovative platform aims to leverage enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high accuracy and...