Project Grant R43GM130198

The National Science Foundation awarded a $249,884 Project Grant to the Regents of the University of Minnesota under the NSF Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to develop a decentralized, on-demand production system for large volume parenteral solutions and medical fluids. The University will implement a proof-of-concept prototype capable of producing 100 L/hr of solutions such as electrolyte replacement, intravenous fluids, and dialysis mixtures on-site...

This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...

Federal Project Grant Award Summary Rochester Institute of Technology received a $373,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with completion targeted for June 30, 2029. The project, "Optimizing Nanobody Sequence Design Through Multi-Objective Engineering," will develop advanced computational and experimental systems to simultaneously predict...

This $299,999 National Science Foundation project grant through the Engineering program (CFDA 47.041) will fund research at California Polytechnic State University, Pomona to develop a computational framework for the design and optimization of dynamic membrane processes. Over the three-year period from June 2022 to May 2025, the grantee will investigate salt retention, fouling, scaling and concentration polarization under transient conditions using computational fluid dynamics modeling. They...

This Project Grant award of $223,806 from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports research at the University of Iowa to optimize the powder compaction process for producing smaller pharmaceutical tablets using multi-tip compaction tooling. The goal is to develop computational modeling techniques to better understand the micromechanical behavior of powders in multi-tip tooling and guide the selection of optimal compaction parameters. This...

This three-year project grant from the National Science Foundation Division of Materials Research, totaling $306,307, will fund research into elucidating the rate-limiting steps of biopolymer dissolution and developing new biopolymer derivatives for oral drug delivery systems. Virginia Polytechnic Institute and State University, doing business as Virginia Tech, will lead the collaborative research effort to understand how additives impact the dissolution rates of polysaccharide derivatives....

This $165,123 project grant from the National Science Foundation's Mathematical and Physical Sciences program will support the development of new computational methods and software tools for predicting polymorphic crystal structures of organic molecules and elucidating phase transition mechanisms. Mark Tuckerman of New York University and Jerome Delhommelle of the University of North Dakota will create a topological theory for crystal structure generation based solely on molecular order...

This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $463,746 to the University of Puerto Rico Medical Sciences Campus (UPR-MSC) to study an innovative continuous crystallizer concept. The objective is to develop robust, scalable, and miniaturized equipment for pharmaceutical manufacturing that can improve resilience to supply chain disruptions and better meet fluctuating market needs. The research seeks to advance continuous...

Federal Grant Award Summary QuantumBio Inc. received a $508,364 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 30, 2025, with a completion date of May 31, 2026. The award supports development of a unified X-ray crystallography and cryo-electron microscopy (cryo-EM) computational toolkit designed to improve structural refinement of protein-ligand complexes. The toolkit...

This $221,000 National Science Foundation project grant funds research at the University of Texas at Dallas to develop a control theoretic framework for modeling protein folding and unfolding pathways. The goal is to enable accurate in silico prediction of protein conformational dynamics with applications in computer-aided drug design, nano-machine control, and treatment of protein misfolding diseases. The researchers will apply optimization-based nonlinear control methods to guide protein...