Project Grant R43GM090418

The National Institute of General Medical Sciences (NIGMS) has awarded a 5-year, $471,019 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Georgia Tech Research Corporation (Georgia Tech Research Corp) to characterize extracellular glycoproteins and study their functions. The project aims to develop innovative mass spectrometry-based methods to comprehensively analyze glycoproteins on cell surfaces and in the secretome, as well as investigate the...

This five-year $1.5 million Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund computer simulations and modeling of G-proteins, molecular machines, and other biomolecules at the University of Southern California. The grant supports research into understanding the control and mediation of life processes by G-proteins and related complexes, the role of ATP in specialized proteins and energy conversion processes, directional motions of...

The National Institute of General Medical Sciences (NIGMS) awarded a $202,467 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Acpharis, a biotechnology software company based in Holliston, Massachusetts. The grant supports the development of a commercial-quality software product that integrates machine learning with physics-based computational approaches to accurately predict the structures of antibody-antigen complexes. This breakthrough technology,...

This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $586,230 to The Leland Stanford Junior University to conduct research on the physical organization and molecular transport mechanisms of the cell membrane glycocalyx. The project aims to develop a fundamental biophysical understanding of how the proteins and sugars that make up the protective "shield" on cell surfaces modulate the interactions of proteins, polysaccharides,...

This Project Grant award of $175,000 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of a modular framework for modeling the binding of peptides and proteins to cell membranes. The key products to be delivered include: A software "mover" implemented in the Rosetta C++ codebase to predict the placement of proteins and peptides in cell membranes, an application of this mover compatible...

The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...

The National Institute of General Medical Sciences (NIGMS) awarded a $382,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Texas A&M Engineering Experiment Station (Tees) for the project "Role of Membrane Dynamics in Cell Surface Glycan Recognition" from January 1, 2025 to December 31, 2029. The goal of this project is to investigate how the spatial organization of glycan ligands on cell membranes influences glycobiology processes, and to develop...

The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...

The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $189,854 to the University of Georgia Research Foundation to develop a combined in vitro and in silico multi-modal platform to study the relationship between cell stiffness and cell motility. The key objectives of this 3-year project are to build custom microfluidic chips to sort cells based on their stiffness,...