The National Institute of Environmental Health Sciences (NIEHS) awarded Nemametrix, Inc. a $296,420 Project Grant under the Environmental Health (CFDA 93.113) federal grant program. The funding will support the development of the ToxiFin Platform, an automated high-throughput screening system for assessing developmental neurotoxicity using the zebrafish model. The ToxiFin Platform aims to provide a cost-effective and efficient alternative to conventional rodent testing methods, with the potential to assess a broader range of chemicals for developmental neurotoxicity, diversify endpoints for detection, and enable effective risk assessment, regulation, and intervention strategies. The project will focus on engineering a transgenic zebrafish line with bioluminescent signals to detect synapse formation (Aim 1) and developing an efficient screen for assessing developmental neurotoxic effects on neural circuit function and central nervous system organization (Aim 2). This research supports the NIEHS mission to understand the interactions between environmental exposures and human health.
Generated 2/25/25, 3:02 AM