This Project Grant award of $275,956 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program aims to develop an engineered cyber-physical system that combines advanced biological models with artificial intelligence methods for predictive, automated screening of anti-cancer drugs and optimization of their dosing. The key products and services to be delivered under this award include: 1) Adoption of 3D bioprinting to generate vascularized ductal...
This Project Grant award, made by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of Dermisphere, an advanced dermal regeneration scaffold product by Fesariustherapeutics Inc. The $349,345 award aims to demonstrate the feasibility of using Dermisphere to manage acute major burn wounds. Preliminary studies have shown that Dermisphere can support rapid and sustained cellular...
This Project Grant award of $170,490 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to develop and validate computable phenotypes for pediatric atopic dermatitis and compare the effectiveness and safety of dupilumab versus methotrexate for treating this condition. The funding will enable The Johns Hopkins University to utilize electronic health...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $295,294 to Biotherapeutics, Inc. for the development of a novel first-in-class topical immunoregulatory therapeutic for the treatment of plaque psoriasis. The key objectives are to: 1) evaluate the permeability and long-term stability of the topical drug product formulation, 2) compare the...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $306,872 to Bioprinting Laboratories Inc. to establish a platform for high-throughput developmental neurotoxicity (DNT) testing using engineered brain organoids. The key products and services to be delivered include: Developing genetically engineered, induced pluripotent stem cells with a promoter-reporter assay system to...
This $900,804 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program supports the development and validation of an integrated microphysiological screening platform (MPS) with "virtual human" models to assess chemical toxicity. The key products and services to be delivered include: A 96-well MPS screening platform that combines elements of the awardee's commercial 48-well MPS with highly...
This $768,122 Project Grant from the National Institute of General Medical Sciences will support the development of statistical software to predict adverse medical events in preterm infants using multi-sensor streaming data. The awardee, William D Shannon Consulting LLC doing business as Biorankings, will develop an algorithm to transform sensor data from neonatal intensive care units into graphical representations of associations. Decision rules from statistical process control will then...
The federal grant award R44LM014736 from the National Institute of Environmental Health Sciences (NIEHS) under the Medical Library Assistance (CFDA 93.879) program supports the development of GUIDEDOR, a real-time medication safety software platform for the operating room. The $313,819 project aims to enhance GUIDEDOR's functionality by adding critical new features such as support for local anesthetic systemic toxicity, glucose management, and perioperative antibiotic management. In Phase I, the...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Abuse and Addiction Research Programs (CFDA 93.279) aims to develop and test a mobile health system prototype for early prediction of chemotherapy-induced peripheral neuropathy (CIPN). The $403,240 award to Newventureiq LLC will fund the development of the "Allo-Cold" mobile app, which will use a patient-reported data collection approach to quantify cold hypersensitivity as an early biomarker for...
This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...