100%
Skip to main content
Platform
GovTribe AI
AI-powered insights to accelerate your government contracting workflow.
MCP Server
Connect GovTribe to your AI tools.
Beacon
Find and connect with key government decision-makers.
Profiles
Federal Agencies
Federal Contract Vehicles
Federal Grant Programs
Major Defense Acquisition Programs
NAICS Categories
PSC Categories
States
Jurisdictions
NIGP Categories
UNSPSC Categories
Vendors
Enrichment By Clearbit
Reports
New Entrants
Funding Analysis
Vehicle Analysis
Groups
Capture
Pipelines
Pursuits
Alerts
Teaming
Data
Awards
Forecasts
Federal Opportunities
State & Local Opportunities
Files
Prime and Subcontractors
Activity
Search
Exports
Solutions
Use Case
Opportunity Identification
Capture Management
Competitive Intelligence
Teaming & Partner Identification
Proposal Management
Strategic Leadership
Go-to-Market Strategy
Industry
Federal Contractors
State & Local Contractors
Grant Seekers
Government Agencies
Research & Consulting
Pricing
More
About Us
Features
Get A Demo
Sign Up
Blog
User Guide
Data Model
GovTribe for Agents
Login
Contact sales
Try for free
Login
Contact sales
Try for free
All Federal Grant Awards
Project Grant R43ES032355
Award Date
8/1/20
Completion Date
1/31/22
Dollars Obligated
$252K
Overview
Activity
3
Transactions
3
Subawards
Similar Awards
Federal Agency
National Institute of Environmental Health Sciences
Awardee
Lena Biosciences, Inc. (HVWSKPM6NUK3)
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
Georgia, USA
Update #1
Update #2
PERFUSED ORGAN PANEL AS AN ANIMAL SURROGATE FOR CHEMICAL TOXICITY TESTING
Posted 7/30/20
5
1
Mod #
Description
ReasonForModification
Federal Obligation
Date
Not listed
PERFUSED ORGAN PANEL AS AN ANIMAL SURROGATE FOR CHEMICAL TOXICITY TESTING - THIS PROJECT RESPONDS TO THE NIEHS RFA-ES-20-005 "ORGANOTYPIC CULTURE MODELS DEVELOPED FROM EXPERIMENTAL ANIMALS FOR CHEMICAL TOXICITY SCREENING," THAT IS ALIGNED WITH THE NEEDS OF THE NTP'S INTERAGENCY CENTER FOR THE EVALUATION OF ALTERNATIVE TOXICOLOGICAL METHODS (NICEATM) FOR DEVELOPMENT AND EVALUATION OF NEW, REVISED, AND ALTERNATIVE METHODS TO IDENTIFY POTENTIAL HAZARDS TO HUMAN HEALTH AND THE ENVIRONMENT. THROUGH OUR ONGOING NCATS SBIR PHASE II, LENA BIOSCIENCES (LB) DEVELOPED AND COMMERCIALIZED AN ORGAN- ON-A-CHIP-LIKE, PERFUSED ORGAN PANEL, WITH A PROPRIETARY LIQUID BREATHING TECHNOLOGY THAT PROVIDES UNIFORM INTERSTITIAL PERFUSION, SUPERIOR DELIVERY OF OXYGEN AND STABLE PH TO 48 STATISTICALLY INDEPENDENT ORGAN CULTURES. IN THIS PROJECT, LENA BIOSCIENCES WILL USE THE PERFUSED ORGAN PANEL TO DEVELOP PHYSIOLOGICALLY-RELEVANT IN VITRO SCREENING SYSTEMS USING CELLS DERIVED FROM ANIMAL SPECIES TYPICALLY UTILIZED FOR TOXICOLOGICAL TESTING. NEXT, LB WILL REPLICATE BIOLOGICAL INTERACTIONS AND TOXICOLOGICAL RESPONSES OBSERVED IN ANIMAL TISSUES. LASTLY, LB WILL PRODUCE ASSAY DATA THAT IS SUITABLE FOR COMPARISONS BETWEEN IN VITRO AND IN VIVO ANIMAL TOXICOLOGY STUDIES, AND TOX21 HTS DATA. ULTIMATELY, THIS PROJECT WILL PROVIDE THOROUGHLY CHARACTERIZED AND VALIDATED, ALTERNATIVE IN VITRO TEST SYSTEMS WITH HIGH SPECIFICITY AND SENSITIVITY TO REDUCE OR REPLACE THE USE OF ANIMALS IN TOXICITY TESTING. IN PHASE I, LB WILL DEVELOP BIOLOGICALLY AND XENOBIOTIC-METABOLICALLY COMPETENT RODENT LIVER AND BRAIN MODELS HAVING IN VIVO LIKE CELLULAR RESPIRATORY METABOLISM TO ACHIEVE OPTIMAL MITOCHONDRIAL RESPONSIVENESS AND SUSCEPTIBILITY TO TOXICANTS. THE LIVER MODEL WILL PROVIDE HIGH ACTIVITY OF DRUG METABOLIZING ENZYMES FOR IN SITU GENERATION OF REACTIVE METABOLITES, AND MIMIC PARALLEL PROCESSES OF PARENT DRUG DELETION AND METABOLITE FORMATION TO BETTER MODEL AND PREDICT TOXICOLOGICAL OUTCOMES. THE BRAIN MODEL(S) WILL MIMIC THE BRAIN'S INNATE IMMUNITY WITH ROBUST TOXICOLOGICAL RESPONSES TO DRUG OVERDOSE, ACETYLCHOLINESTERASE INHIBITION WITH ACUTE NEUROTOXICITY (PHASE I), AND NEUROPATHY TARGET ESTERASE INHIBITION THAT CAUSE DELAYED NEUROPATHY (PHASE II) FOLLOWING THE EXPOSURE TO ORGANOPHOSPHORUS (OP) CHEMICALS AND THEIR TOXIC METABOLITES. PERFUSED ORGAN PANEL AND 3 SETS OF IN VITRO CONTROLS WILL BE TREATED WITH ACETAMINOPHEN (APAP) AND MALATHION, AN OP INSECTICIDE WITH A NEUROTOXIC METABOLITE, MALAOXON, THAT ARE RELEVANT TO THE TESTING OF SPECIFIC TISSUE MODELS AND FOR WHICH SPECIES-MATCHED IN VIVO DATA ALREADY EXISTS. THIS WILL FACILITATE BENCHMARKING AND SHOW THE PERFUSED ORGAN PANEL'S UTILITY AS AN ALTERNATIVE TO IN VIVO MODELS CURRENTLY USED BY THE U.S. ENVIRONMENTAL PROTECTION AGENCY. TO SUCCESSFULLY CARRY OUT THESE STUDIES AND ENSURE THE PROJECT'S SUCCESS, WE ASSEMBLED A TEAM OF EXPERTS IN ADVANCED CELL CULTURE MODELS OF LIVER AND BRAIN (LB'S PI AND CSO, DR. SHOEMAKER), DRUG METABOLISM AND METABOLITE FORMATION (DR. MORGAN, EMORY, DEPARTMENT OF PHARMACOLOGY AND CHEMICAL BIOLOGY), APAP TOXICITY (DR. JAESCHKE, UNIVERSITY OF KANSAS MEDICAL CENTER), AND BRAIN AND LIVER TOXICOLOGY (DR. CAUDLE, EMORY, DEPARTMENT OF ENVIRONMENTAL HEALTH, DR. JAESCHKE, AND DR. MORGAN).
$0
3/24/22
Not listed
PERFUSED ORGAN PANEL AS AN ANIMAL SURROGATE FOR CHEMICAL TOXICITY TESTING - THIS PROJECT RESPONDS TO THE NIEHS RFA-ES-20-005 "ORGANOTYPIC CULTURE MODELS DEVELOPED FROM EXPERIMENTAL ANIMALS FOR CHEMICAL TOXICITY SCREENING," THAT IS ALIGNED WITH THE NEEDS OF THE NTP'S INTERAGENCY CENTER FOR THE EVALUATION OF ALTERNATIVE TOXICOLOGICAL METHODS (NICEATM) FOR DEVELOPMENT AND EVALUATION OF NEW, REVISED, AND ALTERNATIVE METHODS TO IDENTIFY POTENTIAL HAZARDS TO HUMAN HEALTH AND THE ENVIRONMENT. THROUGH OUR ONGOING NCATS SBIR PHASE II, LENA BIOSCIENCES (LB) DEVELOPED AND COMMERCIALIZED AN ORGAN- ON-A-CHIP-LIKE, PERFUSED ORGAN PANEL, WITH A PROPRIETARY LIQUID BREATHING TECHNOLOGY THAT PROVIDES UNIFORM INTERSTITIAL PERFUSION, SUPERIOR DELIVERY OF OXYGEN AND STABLE PH TO 48 STATISTICALLY INDEPENDENT ORGAN CULTURES. IN THIS PROJECT, LENA BIOSCIENCES WILL USE THE PERFUSED ORGAN PANEL TO DEVELOP PHYSIOLOGICALLY-RELEVANT IN VITRO SCREENING SYSTEMS USING CELLS DERIVED FROM ANIMAL SPECIES TYPICALLY UTILIZED FOR TOXICOLOGICAL TESTING. NEXT, LB WILL REPLICATE BIOLOGICAL INTERACTIONS AND TOXICOLOGICAL RESPONSES OBSERVED IN ANIMAL TISSUES. LASTLY, LB WILL PRODUCE ASSAY DATA THAT IS SUITABLE FOR COMPARISONS BETWEEN IN VITRO AND IN VIVO ANIMAL TOXICOLOGY STUDIES, AND TOX21 HTS DATA. ULTIMATELY, THIS PROJECT WILL PROVIDE THOROUGHLY CHARACTERIZED AND VALIDATED, ALTERNATIVE IN VITRO TEST SYSTEMS WITH HIGH SPECIFICITY AND SENSITIVITY TO REDUCE OR REPLACE THE USE OF ANIMALS IN TOXICITY TESTING. IN PHASE I, LB WILL DEVELOP BIOLOGICALLY AND XENOBIOTIC-METABOLICALLY COMPETENT RODENT LIVER AND BRAIN MODELS HAVING IN VIVO LIKE CELLULAR RESPIRATORY METABOLISM TO ACHIEVE OPTIMAL MITOCHONDRIAL RESPONSIVENESS AND SUSCEPTIBILITY TO TOXICANTS. THE LIVER MODEL WILL PROVIDE HIGH ACTIVITY OF DRUG METABOLIZING ENZYMES FOR IN SITU GENERATION OF REACTIVE METABOLITES, AND MIMIC PARALLEL PROCESSES OF PARENT DRUG DELETION AND METABOLITE FORMATION TO BETTER MODEL AND PREDICT TOXICOLOGICAL OUTCOMES. THE BRAIN MODEL(S) WILL MIMIC THE BRAIN'S INNATE IMMUNITY WITH ROBUST TOXICOLOGICAL RESPONSES TO DRUG OVERDOSE, ACETYLCHOLINESTERASE INHIBITION WITH ACUTE NEUROTOXICITY (PHASE I), AND NEUROPATHY TARGET ESTERASE INHIBITION THAT CAUSE DELAYED NEUROPATHY (PHASE II) FOLLOWING THE EXPOSURE TO ORGANOPHOSPHORUS (OP) CHEMICALS AND THEIR TOXIC METABOLITES. PERFUSED ORGAN PANEL AND 3 SETS OF IN VITRO CONTROLS WILL BE TREATED WITH ACETAMINOPHEN (APAP) AND MALATHION, AN OP INSECTICIDE WITH A NEUROTOXIC METABOLITE, MALAOXON, THAT ARE RELEVANT TO THE TESTING OF SPECIFIC TISSUE MODELS AND FOR WHICH SPECIES-MATCHED IN VIVO DATA ALREADY EXISTS. THIS WILL FACILITATE BENCHMARKING AND SHOW THE PERFUSED ORGAN PANEL'S UTILITY AS AN ALTERNATIVE TO IN VIVO MODELS CURRENTLY USED BY THE U.S. ENVIRONMENTAL PROTECTION AGENCY. TO SUCCESSFULLY CARRY OUT THESE STUDIES AND ENSURE THE PROJECT'S SUCCESS, WE ASSEMBLED A TEAM OF EXPERTS IN ADVANCED CELL CULTURE MODELS OF LIVER AND BRAIN (LB'S PI AND CSO, DR. SHOEMAKER), DRUG METABOLISM AND METABOLITE FORMATION (DR. MORGAN, EMORY, DEPARTMENT OF PHARMACOLOGY AND CHEMICAL BIOLOGY), APAP TOXICITY (DR. JAESCHKE, UNIVERSITY OF KANSAS MEDICAL CENTER), AND BRAIN AND LIVER TOXICOLOGY (DR. CAUDLE, EMORY, DEPARTMENT OF ENVIRONMENTAL HEALTH, DR. JAESCHKE, AND DR. MORGAN).
$0
3/24/22
Not listed
PERFUSED ORGAN PANEL AS AN ANIMAL SURROGATE FOR CHEMICAL TOXICITY TESTING
$252.1k
7/30/20