Project Grant R43ES023773

This Project Grant award by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $583,250 to The Schepens Eye Research Institute, Inc. to identify the mechanisms underlying ocular toxicity caused by nitrogen mustard exposure and evaluate specialized lipid mediators as potential medical countermeasures. The key objectives are to: 1) Determine how nitrogen mustard alters the function of conjunctival goblet cells and if...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, supports research to further delineate the mitochondrial involvement in acute and chronic poisoning from organophosphates (OPs). The overarching goal is to investigate the mitochondrial contribution to neurological, cardiac and microcirculation sequelae, with a focus on novel biomarker development and therapy. The $821,373 award to The...

The Department of the Army Medical Command awarded a $1.189 million Project Grant to Children's Hospital Medical Center in Cincinnati, Ohio, to support research on Delayed Outcome Mechanisms in Chronic Traumatic Optic Neuropathy. The three-year award, issued on September 15, 2022 and running through September 14, 2025, will fund research under the Military Medical Research and Development program. This program aims to transform military and public health through innovative medical research...

The University of Wisconsin System, through its Office of Sponsored Programs Division at the University of Wisconsin-Milwaukee (UWM), was awarded a $226,464 Project Grant (R21ES037250) under the Trans-NIH Research Support program (CFDA 93.310) by the National Institutes of Health (NIH). The purpose of this research grant is to demonstrate the therapeutic efficacy of one or more gamma aminobutyric acid type A receptor (GABAAR) modulators in reducing acute lung injury caused by inhaled chlorine...

This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $462,501 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, to conduct research on mast cell activation as a common mechanism of pulmonary toxicity from chemical threat agents. The two-year project aims to examine how activation of mast cells contributes to lung inflammation and injury caused by exposure to various...

The Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded Xplosafe LLC a $500,000 project grant on September 15, 2023. The grant supports Xplosafe's efforts to develop innovative monitoring solutions for assessing environmental and personal exposures to hazardous chemicals. Key objectives include transforming battlefield health care and improving environmental chemical detection capabilities. Xplosafe, a provider of critical safety solutions, will...

This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program provides $498,248 to the University of Connecticut Health Center (UCHC) to investigate the molecular mechanisms underlying corneal and retinal injury caused by exposure to chemical threat agents like nitrogen mustard. The key objectives are to: 1) Examine the role of the p53-PAD axis in driving corneal hypercitrullination, a pathological response, after nitrogen...

The Defense Health Agency awarded a $725,000 Project Grant to the University of Oklahoma Health Sciences Center to develop treatments for cognitive, motor, and sensory outcomes associated with mild traumatic brain injury and post-traumatic stress disorder. Funded through the Military Medical Research and Development program under the Cooperative Agreements and Other Transactions authority, this three-year award beginning April 15, 2023 will support research into modulating the NOP receptor...

This Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) will provide $482,242 to The Medical College of Wisconsin, Inc. to conduct research on the mechanisms of mustard gas toxicity in the retina using a minipig model. The project aims to characterize the in vivo clinical, structural, and functional changes in the retina of a minipig model exposed to mustard gas, and identify molecular targets involved in retinal degenerative...

This $732,500.00 Project Grant award from the Defense Health Agency supports research by Mississippi State University on the "Neurochemical and Behavioral Effects Following Repeated-Dose Pyridostigmine Bromide and Sublethal Organophosphate Challenge." The award is funded through the Military Medical Research and Development program (CFDA 12.420), which supports basic, applied, and advanced biomedical research to improve healthcare for Service Members and the public. Over the 3-year...