Project Grant R43ES023522

The National Institute of Environmental Health Sciences (NIEHS) awarded University of Hawaii at Manoa a Project Grant of $156,500 under the Environmental Health program (CFDA 93.113) on April 9, 2026, with completion anticipated by April 8, 2028. This grant supports the development and validation of new approach methodologies (NAMs) for developmental and reproductive toxicity (DART) assessment using morphogenesis models derived from pluripotent stem cells. The project deliverables include...

This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...

The National Institute of Environmental Health Sciences (NIEHS) awarded Xcellassay, Inc. a $306,872 Project Grant under the Environmental Health (CFDA 93.113) federal grant program. The grant funding will support the development and characterization of a hand-held, bioassay-based test strip for rapid, in-field detection of water contamination by endocrine-disrupting chemicals (EDCs). The goal is to create a 1 x 1.5 cm detection strip printed with 20 nuclear receptor sensors that can be...

Federal Project Grant Award Summary Millennium Bioresearch, Inc. (doing business as MB Research Laboratories) received a $259,274 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) for the period July 1, 2026 through June 30, 2027. The award supports development of the Egg LD50 Assay for Categorization (ELDAC), an in vitro alternative testing methodology designed to replace traditional mammalian acute oral...

Ortuvo LLC received a $256,000 Project Grant award from the National Science Foundation on June 1, 2021 to develop a fully screen printed electric cell-substrate impedance sensing toxicity assay. The award is part of the NSF's Technology, Innovation, and Partnerships program (CFDA 47.084), which seeks to advance science, engineering, and innovation leading to breakthrough technologies and solutions to national challenges. Under the one-year project period ending November 30, 2022, Ortuvo will...

Summary The National Institutes of Health (NIH) Office of the Director awarded a $3.12 million Cooperative Agreement (CFDA 93.310, Trans-NIH Research Support) to Texas A&M Agrilife Research, effective March 2, 2026, through December 31, 2030, to establish the NAMS-Decisions Center for integrating New Approach Methodologies (NAMs) into regulatory decision-making for chemical safety assessment. The center delivers defined approaches for using in vitro and in silico NAMs to enhance...

Javelin Biotech Inc. received a $349,677 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective July 1, 2026, with completion scheduled for December 31, 2026. Under this award, Javelin is investigating the impact of metabolic disease states on the pharmacodynamics and toxicity of four FDA-approved antisense oligonucleotide (ASO) drugs using its Liver Tissue Chip Plus platform integrated with kidney tissue models. The project addresses...

This $156,500 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to establish an in vitro model of the human yolk sac using human pluripotent stem cells. The University of Hawaii is the primary awardee and will characterize the stem cell-derived yolk sac organoid to assess its functional similarities to the human yolk sac. They will also examine the effects of high glucose levels on the...

Amelia Technologies LLC received a $303,165 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), with an award date of August 19, 2025 and completion date of July 31, 2026. The award supports the development and advancement of SphereDNA, a novel high-throughput genotoxicity screening platform that addresses critical gaps in toxicity assessment for engineered nanomaterials (ENMs). SphereDNA utilizes...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $379,504 to the University System of New Hampshire's Keene State College to conduct research on the tissue-specific development of toxicity in response to transgenerational chronic arsenic exposures. The key objectives are to: (1) detect tissue-specific uptake of arsenic in response to transgenerational chronic exposure; (2)...