Project Grant R43EB038821
- The National Institute of Biomedical Imaging and Bioengineering awarded The Johns Hopkins University $507,987 on April 23, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop scintillator-based photon counting detectors for X-ray computed tomography systems. The research addresses cost and image quality barriers in photon counting detector CT technology by replacing semiconductor-based detectors with...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Tennessee, operating as the Space Institute, $157,000 on April 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The recipient will develop novel structured glass-ceramic scintillator conversion screens to improve image quality and reduce dose in X-ray imaging applications using indirect flat panel detectors at megavoltage...
- The National Institute of Biomedical Imaging and Bioengineering awarded $161,000 to the University of California, Davis on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop an affordable dynamic total-body positron emission tomography (TB PET) imaging system using sparse detector architectures. The research addresses cost barriers to TB PET adoption by reducing scintillator material and readout electronics...
- The National Institute of Biomedical Imaging and Bioengineering awarded Mayo Clinic $625,527 on April 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop methods for non-invasive coronary artery imaging using photon-counting detector CT and artificial intelligence. The award funds research to overcome limitations in cardiac CT imaging that prevent accurate visualization of coronary stenosis in patients with...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Davis $615,615 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop next-generation whole-body positron emission tomography (PET) scanners with enhanced spatial resolution and timing performance. The research aims to achieve sub-2 millimeter spatial resolution and approximately 8 cubic millimeter...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Regents of the University of California, operating Lawrence Berkeley National Laboratory, $312,165 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop Time-of-Flight Multi-Photon Emission Tomography (TOF-MPET) for direct imaging of therapeutic radionuclides in cancer treatment. The project addresses limitations in current imaging...
- The National Institute of Biomedical Imaging and Bioengineering awarded Mayo Clinic $620,179 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to implement, optimize, and validate charge-sharing-correction techniques on a whole-body photon-counting-detector CT scanner for vascular plaque characterization. The project addresses spectral degradation caused by charge sharing in photon-counting-detector CT systems,...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Johns Hopkins University $621,956 on August 12, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop artificial intelligence algorithms that detect very small pancreatic, hepatobiliary, and upper gastrointestinal cancers in computed tomography scans. The research addresses the late-stage detection problem in these disease categories, which...
- The National Institute of Biomedical Imaging and Bioengineering awarded Northeastern University $219,818 on April 27, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a fully integrated electro-optic sensor for real-time MRI-guided interventions. The award funds development of an interventional device sensor that addresses safety and imaging limitations in MRI-guided procedures. Current active devices for...
- The National Institute of Biomedical Imaging and Bioengineering awarded Massachusetts General Hospital $247,500 on June 6, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a miniaturized scanning light endoscope with no moving parts for high-speed three-dimensional deep imaging in live biological systems. The recipient will leverage potassium tantalate niobite (KTN) crystal technology to create a compact optical...
The National Institute of Biomedical Imaging and Bioengineering, part of the Department of Health and Human Services, awarded $329,058 to Actinia Inc. on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286, Assistance Listing program R43EB038821) to develop high-resolution energy-integrating computed tomography scanners using direct-conversion detectors made from cesium lead bromide. Current X-ray CT instruments rely on energy-integrating detectors based on indirect-conversion scintillator materials, which present manufacturing complexity, supply-chain challenges, thermal management requirements, and inherent spatial resolution limits. Direct-conversion detector technology addresses these constraints by converting X-rays into electron-hole pulses detected electronically, enabling better energy and spatial resolution, shorter scan times, lower radiation doses, and sharper images. While photon-counting CT instruments based on direct detectors have reached the market for high-end applications, no general-use energy-integrating CT instrument utilizing direct detectors has yet been commercialized. This project aims to advance direct-detector technology for mainline diagnostic X-ray CT applications. The work will be performed in Evanston, Illinois over a twelve-month period of performance ending August 31, 2027. The award is a Project Grant, a form of assistance funding supporting hypothesis- and technology-driven research in biomedical imaging and bioengineering.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $329.1k | 8/21/26 |