Project Grant R43EB029863

This $305,000 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a clinical decision support system (CDSS) called Sepsis FLO. The CDSS is designed to precisely guide blood volume diagnosis and treatment for sepsis patients. Key activities include: 1) Developing an alpha prototype of the CDSS through user-centered design; 2) Validating three functional...

This federal Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $274,858 to New England Hemolytics, Inc. to advance the development of a novel technology for the rapid and automated extraction of pathogen DNA from venous whole blood samples. The goal is to significantly decrease the time to diagnose sepsis from 1-5 days to less than an hour, enabling faster treatment and improving patient outcomes. The...

This $1,165,298 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop novel nanopore- and click-chemistry-based approaches for rapid, culture-independent detection of sepsis-causing pathogens directly from blood samples within 2 hours. The project will engineer nanopore biosensors and multiplex click chemistry-amplified nanopore sensing to target proteomic biomarkers like outer...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,583,391 in funding to The Regents of the University of California, San Francisco (UCSF) over a period of approximately 5 years, beginning June 21, 2024. The primary objectives of this research project are to: 1) Identify known and novel pathogens responsible for septic shock using metagenomic sequencing;...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $298,646 to Anvil Diagnostics Inc., a minority-owned small business located in Cambridge, MA, is for the development of a rapid, ultra-sensitive, and multiplexed diagnostic test for detecting sepsis-causing pathogens in neonates. The proposed DNA-based technology aims to comprehensively identify and quantify a wide range of pathogens from small blood volumes in under 4 hours, a...

The National Institutes of Health (NIH) has awarded a $150,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Ohio State University to develop a human-centered artificial intelligence (HCAI) system that will collaborate with healthcare professionals to improve early prediction and decision-making for sepsis. The key objectives are to: 1) create a comprehensive sepsis-related electronic health record (EHR) database, 2) develop advanced machine learning models...

This $455,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports a research program to decrease pediatric sepsis mortality. The key products and services to be delivered include: Development of an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Conducting sepsis phenotyping and creating digital twin patient models to predict personalized...

This federal Project Grant award of $412,250.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support the development of a continuous, real-time, automated smart catheter analyzer for early identification of sepsis through urine biomarkers. The project, led by Arizona State University, aims to enable clinicians to quickly respond and support heart and lung function in sepsis patients. The smart catheter analyzer will be designed for use by...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $700,000 to Prenosis, Inc., a small disadvantaged business in Chicago, Illinois, to validate and demonstrate the capabilities of the company's Immunix platform for precision medicine patient stratification and endotyping of sepsis patients. The Immunix platform combines clinical data, novel biomarker assays, and AI-enabled tools...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Macula Vision Systems Inc., a for-profit organization, supports the development of a novel microscopy platform to automate the interpretation of microbiology lab tests performed in hospitals. The project aims to address the shortage of trained lab technicians by engineering a specialized light source, customized camera, and AI-enabled algorithms to analyze...